Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds.
Two-Minute Quantitative Susceptibility Mapping From Three-Dimensional Echo-Planar Imaging: Accuracy, Reliability, and Detection Performance in Patients With Cerebral Microbleeds.
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三维回波平面成像的两分钟定量磁敏图：脑微出血患者的准确性、可靠性和检测性能。
DOI：
10.1097/rli.0000000000000708
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Nakamoto Y.
中科院分区：
文献类型：
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作者：
Wicaksono KP;Fushimi Y;Nakajima S;Yokota Y;Oshima S;Otani S;Sakurama A;Shima A;Sawamoto N;Okada T;Nakamoto Y.
本研究的目的是评价三维回波平面成像(3D-EPI)2分钟定量磁化率图(QSM)检测脑微出血(CMB)的准确性、可靠性和性能。材料与方法在两台3-T磁共振(MR)扫描仪上，使用3D-EPI、单次回波时间(TE)和多TE梯度回波(GRE)序列对Gd体模进行研究，以评估测量的磁化率值与理论磁化率值之间的准确性。机构审查委员会批准了这项前瞻性研究，40名健康志愿者在2018年4月至2019年10月期间进行了书面同意。在一台3-T磁共振扫描机上连续进行3D-EPI、单TE和多TE GRE序列，并计算QSM以评估3D-EPI QSM的可靠性。计算组内相关系数(ICC)、线性回归和Bland-Altman图。对同时接受3D-EPI和GRE QSM扫描的CMB患者进行回顾性研究。结果模型研究显示3D-EPI QSM在两种MR上的有效性良好：Skyra，R2=0.996，P<；0.001，ICc=0.997，平均差，−2 ppb(95%可信区间[CI]，−45~40 ppb)；PRISMA，R2=0.992，P<；0.001，ICC=0.988，平均差15 ppb(95%CI，−67~97 ppb)。一项对40名健康志愿者(59±13岁，25名女性)的人体研究显示，3D-EPI QSM对单TE和多TE GRE都具有极好的可靠性(R2=0.981，P<；0.001，ICC=0.988；R2=0.983，P<；0.001，ICC=0.990)，单TE GRE的Bland-Altman平均差为4 ppb(95%CI，−15~23 ppb)，多TE GRE的3D-EPI QSM平均差为3 ppb(95%CI，−15~20 ppb)。38例患者(51±20岁，女性20例)的CMB检测结果显示，3D-EPI和GRE QSM在两个评定者中几乎完全一致(κ=0.923和0.942，P<；0.001)。
ObjectivesThe aim of this study was to assess the accuracy, reliability, and cerebral microbleed (CMB) detection performance of 2-minute quantitative susceptibility mapping (QSM) from 3-dimensional echo-planar imaging (3D-EPI).Materials and MethodsGadolinium phantom study was conducted using 3D-EPI, single–echo time (TE), and multi-TE gradient-recalled echo (GRE) sequences on two 3-T magnetic resonance (MR) scanners to assess the accuracy between measured and theoretical susceptibility values. The institutional review board approved this prospective study, and 40 healthy volunteers were enrolled with written consent between April 2018 and October 2019. Each underwent 3D-EPI, single-TE, and multi-TE GRE sequences consecutively on one 3-T MR scanner, and QSMs were calculated to assess the reliability of 3D-EPI QSM. Intraclass correlation coefficient (ICC), linear regression, and Bland-Altman plots were calculated. Patients with CMB who underwent both 3D-EPI and GRE QSM scans were retrospectively enrolled. Two radiologists evaluated images independently, and Cohen κ coefficients were calculated to compare CMB detection performance.ResultsPhantom study showed excellent validity of 3D-EPI QSM on both MR scanners: Skyra, R 2= 0.996, P< 0.001, ICC= 0.997, mean difference,− 2 ppb (95% confidence interval [CI],− 45 to 40 ppb); Prisma, R 2= 0.992, P< 0.001, ICC= 0.988, mean difference, 15 ppb (95% CI,− 67 to 97 ppb). A human study of 40 healthy volunteers (59±13 years, 25 women) showed excellent reliability with 3D-EPI QSM for both single-TE and multi-TE GRE (R 2= 0.981, P< 0.001, ICC= 0.988; R 2= 0.983, P< 0.001, ICC= 0.990, respectively), supported by a Bland-Altman mean difference of 4 ppb (95% CI,− 15 to 23 ppb) for single-TE GRE and 3 ppb (95% CI,− 15 to 20 ppb) for multi-TE GRE. The CMB detection performance evaluation from 38 patients (51±20 years, 20 women) showed almost perfect agreement between 3D-EPI and GRE QSM for both raters (κ= 0.923 and 0.942, P< 0.001).Conclusions