PROLACTIN BRAIN INTERACTIONS IN THE INDUCTION OF MATERNAL-BEHAVIOR IN RATS
PROLACTIN BRAIN INTERACTIONS IN THE INDUCTION OF MATERNAL-BEHAVIOR IN RATS
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DOI：
10.1016/0306-4530(94)90045-0
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发表时间：
1994-01-01
影响因子：
3.7
通讯作者：
MANN, PE
中科院分区：
文献类型：
--
作者：
BRIDGES, RS;MANN, PE
大多数成年雌性哺乳动物在分娩时会立即对后代表现出母性关怀，而缺乏经验的未生育雌性动物的反应往往不那么强烈或不存在。从未产雌性动物中的缓慢或无反应者转变为经产动物中分娩时的快速反应者，部分是由妊娠的内分泌变化引起的。这份报告回顾了最近的证据表明，催乳素在大鼠母性行为的刺激中的作用。此外，露水的研究结果表明，内源性大鼠催乳素的行为集中刺激母体的行为在类固醇引发，nulliparous大鼠和腹内侧下丘脑除了内侧视前区是重要的神经基质调节产妇分娩时的行为的快速诱导。
Most adult female mammals display an immediate onset of maternal care toward their offspring at parturition, whereas the responses of inexperienced, nulliparous females are often less intense or absent. The shift from being a slow or nonresponder in nulliparous females to a rapid responder at parturition in primiparous animals is induced in part by the endocrine changes of pregnancy. This report reviews recent evidence demonstrating a role for prolactin in the stimulation of maternal behavior in the rat. Moreover, dew findings are presented that indicate that endogenous rat prolactin acts centrally to stimulate maternal behavior in steroid-primed,nulliparous rats and that the ventromedial hypothalamus in addition to the medial preoptic area are important neural substrates regulating the rapid induction of maternal behavior at parturition.