NEURAL TUNING FOR SOUND DURATION - ROLE OF INHIBITORY MECHANISMS IN THE INFERIOR COLLICULUS
NEURAL TUNING FOR SOUND DURATION - ROLE OF INHIBITORY MECHANISMS IN THE INFERIOR COLLICULUS
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DOI：
10.1126/science.8171341
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发表时间：
1994-05-06
期刊：
影响因子：
56.9
通讯作者：
COVEY, E
中科院分区：
文献类型：
--
作者：
CASSEDAY, JH;EHRLICH, D;COVEY, E
持续时间是声音的生物学重要特征。大棕蝠下丘的一些神经元被调谐到声音的持续时间，但目前还不清楚调谐起源于什么水平或负责它的神经机制。抑制性神经递质γ-氨基丁酸或甘氨酸的拮抗剂在下丘的神经元的应用消除了持续时间调谐。突触电流的全细胞膜片钳记录表明，抑制产生一个时间框架内，兴奋可以发生。提出了一个模型，在该模型中，持续时间调谐时出现的早期，持续的抑制性输入与延迟，瞬态兴奋性输入相互作用。
Duration is a biologically important feature of sound. Some neurons in the inferior colliculus of the big brown bat, Eptesicus fuscus, are tuned to sound duration, but it is unclear at what level the tuning originates or what neural mechanisms are responsible for it. The application of antagonists of the inhibitory neurotransmitters gamma-aminobutyric acid or glycine to neurons in the inferior colliculus eliminated duration tuning. Whole-cell patch-clamp recordings of synaptic currents suggested that inhibition produces a temporal frame within which excitation can occur. A model is proposed in which duration tuning arises when an early, sustained inhibitory input interacts with a delayed, transient excitatory input.