Quality of Life of Patients With Recurrent Respiratory Papillomatosis
Quality of Life of Patients With Recurrent Respiratory Papillomatosis
复制标题
复发性呼吸道乳头状瘤病患者的生活质量
DOI：
10.1002/lary.26413
复制
发表时间：
2017-08-01
期刊：
影响因子：
2.6
通讯作者：
Dikkers, Frederik G.
中科院分区：
文献类型：
--
作者：
San Giorgi, Michel R. M.;Aaltonen, Leena-Maija;Dikkers, Frederik G.
目的/假设：复发性呼吸道乳头状瘤病（RRP）是一种高疾病负担的疾病。很少有研究评估RRP患者的生活质量（QoL）。本研究比较了这些患者与对照组的生活质量。QoL和社会人口统计学和疾病相关因素之间的关联进行了检查，因为是心理社会护理和言语治疗的摄取。来自荷兰和芬兰的两家大学医院的患者（应答率= 67%）完成了以下患者报告的结局指标：采用健康相关生活质量量表（HADS）、15维健康相关生活质量量表（15 D）、嗓音障碍指数（VHI）和兰德36项健康相关生活质量调查量表（兰德-36）评估健康相关生活质量和嗓音障碍，并提供社会人口学、疾病相关、和相关医疗保健用途。描述性分析，卡方检验，t检验，方差分析和皮尔逊相关性进行计算，以描述研究人群，并检查groups.Results之间的差异：RRP患者有显着较高的平均得分抑郁症，健康相关的生活质量（15 D）和语音问题（VHI），并显着降低平均得分焦虑比对照组。与对照组相比，荷兰患者有更多的疼痛和降低的一般健康感知（兰德-36）。荷兰患者和老年患者更抑郁，女性更焦虑，老年患者有较低的健康相关生活质量，吸烟与语音障碍显着相关。接受心理社会护理的患者有显着较高的HADS抑郁的平均分数比患者谁没有接受心理社会care.Conclusions：有RRP语音相关的生活质量和抑郁有显着的影响，但焦虑和健康相关的生活质量没有负面影响。功能下降的风险因素与许多作者先前假设的不同。预防应针对这些危险因素。
Objectives/Hypothesis: Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness-related factors are examined, as is uptake of psychosocial care and speech therapy.Study Design: Prospective cross-sectional questionnaire research.Methods: Ninety-one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15-dimensional health-related quality-of-life scale (15D), Voice Handicap Index (VHI) and the RAND 36-item health-related quality-of-life survey instrument (RAND-36) assessing health-related QoL and voice handicap, and they provided sociodemographic, illness-related, and allied healthcare use. Descriptive analyses, chi(2) tests, t tests, analysis of variance tests, and Pearson correlations were computed to describe the study population and to examine differences between groups.Results: RRP patients had significantly higher mean scores on depression, health-related QoL (15D) and on voice problems (VHI), and significantly lower mean scores on anxiety than controls. Dutch patients had more pain and a decreased general health perception (RAND-36) than controls. Dutch patients and older patients were more depressed, women were more anxious, older patients had lower health-related QoL, and smoking was significantly associated with voice handicap. Patients who had received psychosocial care had significantly higher HADS-depression mean scores than patients who did not receive psychosocial care.Conclusions: Having RRP has significant effect on voice-related QoL and depression, but has no negative effect on anxiety and health-related QoL. Risk factors for decreased functioning are different than previously hypothesized by many authors. Prevention should be aimed at these risk factors.