Predictions derived from modelling the hippocampal role in navigation
Predictions derived from modelling the hippocampal role in navigation
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DOI：
10.1007/s004220000172
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发表时间：
2000-09-01
影响因子：
1.9
通讯作者：
O'Keefe, J
中科院分区：
文献类型：
--
作者：
Burgess, N;Jackson, A;O'Keefe, J
综述了大鼠导航损伤和单单元数据的计算模型。该模型使用来自环境的外部（视觉）和内部（里程）信息来驱动模拟海马位置细胞的放电。对这些输入的功能形式的限制是从使用可修改形状的环境的实验中得出的。位置细胞表征通过突触强度的Hebbian修饰来创建目标位置表征来指导导航。该模型考虑了相对于海马体脑电图的θ节律的位置细胞放电阶段。对大鼠行为和单单位数据的一系列预测来自模型的输入和输出表示。
A computational model of the lesion and single unit data from navigation in rats is reviewed. The model uses external (visual) and internal (odometric) information from the environment to drive the firing of simulated hippocampal place cells. Constraints on the functional form of these inputs are drawn from experiments using an environment of modifiable shape. The place cell representation is used to guide navigation via the creation of a representation of goal location via Hebbian modification of synaptic strengths. The model includes consideration of the phase of firing of place cells with respect to the theta rhythm of hippocampal EEG. A series of predictions for behavioural and single-unit data in rats are derived from the input and output representations of the model.