Gestational surrogacy for women with recurrent pregnancy loss due to refractory chronic histiocytic intervillositis
Gestational surrogacy for women with recurrent pregnancy loss due to refractory chronic histiocytic intervillositis
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因难治性慢性组织细胞绒毛间炎导致反复流产的女性的妊娠代孕
DOI：
10.1111/1471-0528.17522
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Cornish E
中科院分区：
文献类型：
--
作者：
Cornish E
2. 方法患有一例或多例经组织学证实的 CHI 病例且随后接受 IVF 和妊娠代孕的女性有资格纳入。符合资格的女性是通过国际在线 CHI 支持小组确定的。收集自体妊娠和代孕妊娠的妊娠结果数据。使用 INTERGROWTH‐21st 计算器 (http://intergrowth21.ndog.ox.ac.uk/en/ManualEntry) 计算出生体重百分位。这项研究得到了伦敦研究伦理委员会（富勒姆，19/LO/0105）的批准。所有参与者均提供了发表的书面知情同意书。3．结果 13 名患有复发性 CHI 的女性参与了这项研究。这些女性自己怀孕了 54 次（51 名单胎，3 名双绒毛膜双羊膜双胞胎）。这些妊娠导致围产期不良结局发生率很高（表 1）。在 9 个活产婴儿中，有 2 个在新生儿期死亡（2/9，22%），这意味着只有 7/54 次怀孕（13%）生下了幸存的孩子。在 8/54 (15%) 的妊娠中，母亲接受了产前免疫抑制，包括泼尼松龙、羟氯喹、他克莫司和静脉注射免疫球蛋白中的一种或多种。在尝试自己怀孕后，所有 13 名女性都使用自己的卵母细胞和伴侣的精子进行了体外受精，然后将胚胎移植到代孕母亲体内。这导致了 17 例成功的代孕受孕（12 例单胎，5 例双绒毛膜双羊膜双胞胎），其中 15/17（88%）以正常出生体重的足月或近足月活产结束。剩下的两次妊娠均以妊娠早期流产告终，一次是由于胎儿 21 三体性，另一次则不明原因。曾有两次胚胎移植失败。没有代孕母亲接受免疫抑制。
2. METHODSWomen with one or more histologically proven cases of CHI who had subsequently undergone IVF and gestational surrogacy were eligible for inclusion. Eligible women were identified through an international online CHI support group. Pregnancy outcome data from autologous and surrogate pregnancies were collected. Birthweight centiles were calculated using the INTERGROWTH‐21st calculator (http://intergrowth21. ndog. ox. ac. uk/en/ManualEntry). This study was approved by the London Research Ethics Committee (Fulham, 19/LO/0105). All participants provided written informed consent for publication.3. RESULTSThirteen women with recurrent CHI participated in the study. These women had carried 54 pregnancies themselves (51 singletons, 3 dichorionic‐diamniotic twins). These pregnancies resulted in high rates of adverse perinatal outcomes (Table 1). Of the nine babies born alive, two died in the neonatal period (2/9, 22%), meaning only 7/54 pregnancies (13%) resulted in surviving children. In 8/54 (15%) pregnancies, the mother received antenatal immunosuppression including one or more of prednisolone, hydroxychloroquine, tacrolimus and intravenous immunoglobulin. Following attempts to carry a pregnancy themselves, all 13 women underwent IVF using their own oocytes and their partner's sperm, followed by embryo transfer into a surrogate mother. This led to 17 successful surrogate conceptions (12 singletons, 5 dichorionic‐diamniotic twins), of which 15/17 (88%) ended in term or near‐term live birth with normal birthweight. The two remaining pregnancies ended in first‐trimester miscarriage, one due to fetal trisomy 21 and the other with no identified cause. There were two failed embryo transfers. None of the surrogate mothers received immunosuppression.
影响因子：
9.8
作者：
Benachi, Alexandra;Rabant, Marion;Zuber, Julien
通讯作者：
Zuber, Julien
病因不明的慢性绒毛间炎 (CIUE)：三级转诊机构的患病率、模式和生殖结果。
影响因子：
3.8
作者：
Natasha K. Simula;J. Terry;N. Kent;J. Robertson;S. Purkiss;D. Bloomenthal;Christina Williams;M. Bedaiwy
通讯作者：
M. Bedaiwy
影响因子：
3.6
作者：
Reus, Averil D.;van Besouw, Nicole M.;Exalto, Niek
通讯作者：
Exalto, Niek