TRANSFORMATION OF SPOROZOITES OF PLASMODIUM-BERGHEI INTO EXOERYTHROCYTIC FORMS IN THE LIVER OF ITS MAMMALIAN HOST
TRANSFORMATION OF SPOROZOITES OF PLASMODIUM-BERGHEI INTO EXOERYTHROCYTIC FORMS IN THE LIVER OF ITS MAMMALIAN HOST
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DOI：
10.1007/bf00217180
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
MEUWISSEN, JHET
中科院分区：
文献类型：
--
作者：
MEIS, JFGM;VERHAVE, JP;MEUWISSEN, JHET
本文用免疫荧光、光镜和电镜观察了鼠疟原虫子孢子在体内肝细胞内向幼营养期红细胞外组织的转化。前20小时的细胞内生活完全参与去分化与有限的细胞器增殖。从20 h开始，细胞核开始分裂，粗面内质网明显扩张，线粒体数量增多。然而，子孢子表膜的残留物（即，内膜和膜下微管）持续至少28小时，这与年轻的外红细胞形式与抗子孢子抗体的持续反应有关。一般来说，转化的基本机制类似于动合子转化为卵囊和裂殖子转化为红细胞滋养体。
Intrahepatocytic transformation in vivo of the rodent malaria sporozoite ofPlasmodium berghei, into the young trophic exoerythrocytic tissue stage was studied by immunofluorescence, light- and electron microscopy. The first 20 h of intracellular life were involved entirely in dedifferentiation with limited proliferation of organelles. From about 20 h onwards nuclear division commenced, rough endoplasmic reticulum became markedly expanded, and mitochondria increased in numbers. However, remains of the sporozoite pellicle (i.e., inner membranes and subpellicular microtubules) persisted for at least 28 h, which correlates with the persisting reaction of young exoerythrocytic forms with antisporozoite antibodies. In general, the basic mechanism of transformation resembles that of the ookinete into oocyst and that of the merozoite into erythrocytic trophozoite.