Novel bile acids from bear bile powder and bile of geese.
Novel bile acids from bear bile powder and bile of geese.
复制标题
DOI：
10.1248/cpb.57.528
复制
发表时间：
2009-05
影响因子：
1.7
通讯作者：
Dan Bi;Xingyun Chai;Yuelin Song;Y. Lei;P. Tu
中科院分区：
文献类型：
--
作者：
Dan Bi;Xingyun Chai;Yuelin Song;Y. Lei;P. Tu
从熊胆粉中分离得到两种新的胆汁酸：牛磺鹅胆酸（1）和牛磺鹅胆酸（2）;从鹅胆汁中分离得到一种新的天然胆汁酸：鹅胆酸（3）。经MS、1D和2D NMR等波谱分析，确定新化合物的结构为3 α，7 α，9 α-三羟基-5 β-胆烷-24-酸N-[2-磺乙基]酰胺（1）、3 α，5，7 α-三羟基-5 β-胆烷-24-酸N-[2-磺乙基]酰胺（2）和3 α，7 α，15 α-三羟基-5 β-胆烷-24-酸（3）。
Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus, together with seven known compounds. By spectrum analysis of MS, 1D and 2D NMR, the structures of the new compounds were elucidated as 3alpha,7alpha,9alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (1), 3alpha,5,7alpha-trihydroxy-5beta-cholan-24-oic acid N-[2-sulfoethyl] amide (2) and 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid (3).