Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017.
Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017.
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DOI：
10.3390/microorganisms9071420
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发表时间：
2021-06-30
期刊：
影响因子：
4.5
通讯作者：
The Eu-Tick-Bo Study Group
中科院分区：
文献类型：
--
作者：
Kohlmaier B;Schweintzger NA;Sagmeister MG;Švendová V;Kohlfürst DS;Sonnleitner A;Leitner M;Berghold A;Schmiedberger E;Fazekas F;Pichler A;Rejc-Marko J;Růžek D;Dufková L;Čejková D;Husa P;Pýchová M;Krbková L;Chmelík V;Štruncová V;Zavadska D;Karelis G;Mickiene A;Zajkowska J;Bogovič P;Strle F;Zenz W;The Eu-Tick-Bo Study Group
蜱传脑炎（TBE）病毒是流行国家中枢神经系统感染的主要原因。在这里，我们使用统一的临床方案介绍了一个大型国际确诊TBE患者队列的临床和实验室特征。2010年至2017年期间，来自6个欧洲国家的8个中心招募了患者。记录临床体征和症状的详细描述。所获得的信息使555例患者中的553例能够进行可靠的分类：207脑膜炎273例（37.3%）脑膜脑炎15例（49.2%）脑膜炎占2.7%，脑膜脑脊髓炎10.5%; 41例（7.4%）患者有四肢周围性麻痹，13例（2.3%）有四肢中枢性麻痹，25例（4.5%）有单一或多个颅神经麻痹。5例（0.9%）患者在急性疾病期间死亡。记录了298例患者的出院结局。在176例（59.1%）恢复不完全的患者中，80例（27%）表现出持续的症状或体征，无恢复预期。这项研究提供了进一步的证据，表明TBE是一种严重的疾病，有很大比例的患者恢复不完全。我们建议在流行的欧洲国家使用统一的协议来监测TBE，以记录疾病的全部临床谱。
Tick-borne encephalitis (TBE) virus is a major cause of central nervous system infections in endemic countries. Here, we present clinical and laboratory characteristics of a large international cohort of patients with confirmed TBE using a uniform clinical protocol. Patients were recruited in eight centers from six European countries between 2010 and 2017. A detailed description of clinical signs and symptoms was recorded. The obtained information enabled a reliable classification in 553 of 555 patients: 207 (37.3%) had meningitis, 273 (49.2%) meningoencephalitis, 15 (2.7%) meningomyelitis, and 58 (10.5%) meningoencephalomyelitis; 41 (7.4%) patients had a peripheral paresis of extremities, 13 (2.3%) a central paresis of extremities, and 25 (4.5%) had single or multiple cranial nerve palsies. Five (0.9%) patients died during acute illness. Outcome at discharge was recorded in 298 patients. Of 176 (59.1%) patients with incomplete recovery, 80 (27%) displayed persisting symptoms or signs without recovery expectation. This study provides further evidence that TBE is a severe disease with a large proportion of patients with incomplete recovery. We suggest monitoring TBE in endemic European countries using a uniform protocol to record the full clinical spectrum of the disease.