Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patient's for tuberculosis
Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patient's for tuberculosis
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DOI：
10.1016/j.rmed.2006.01.014
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发表时间：
2006-10-01
影响因子：
4.3
通讯作者：
Acican, Turan
中科院分区：
文献类型：
--
作者：
Gulbay, Banu Eris;Gurkan, Ozlem Ural;Acican, Turan
目的：最常用的抗结核药物的副作用可能是轻微的，也可能是致命的。本研究的目的是评估的副作用和发展副作用对抗anti-TB drugs.Patients和方法的危险因素：1149例结核病患者最初接受抗结核治疗的记录进行了回顾性评价。主要的副作用，导致明确终止从一个或多个药物相关的抗TB治疗，并与这些副作用的危险因素进行了analysed.Results：95例（8.3%），占104例，发生副作用。虽然药物反应的频率从20岁以下的0.6%增加到20-40岁的5.2%，但在有副作用和没有副作用的患者之间没有观察到性别或年龄差异。在开始抗结核治疗的患者中，56例（4.9%）出现白色无症状肝功能障碍，本研究发现肝毒性的发生率为2.4%。在有肝毒性和没有肝毒性的患者中没有观察到年龄或性别差异。主要副作用为耳毒性（1.7%），肝毒性（0.8%），神经精神症状（0.7%）和高尿酸血症（0.6%）。必须记住，抗结核药物引起的严重副作用的发生频率不同，特别是在因肺结核住院的患者中，对这些患者应进行随访，密切监测抗结核药物的副作用。(c)2006爱思唯尔有限公司保留所有权利。
Objective: Side effects of the most commonly used primary antituberculosis (anti-TB) drugs may be mild as well as fatal. The aim of this study was to evaluate the side effects of and the risk factors for developing side effects against anti-TB drugs.Patients and methods: Records of 1149 patients with established tuberculosis who initially received anti-TB therapy were evaluated retrospectively. The major side effects, which resulted in a definitive termination from 1 or more drugs related to anti-TB therapy, and the risk factors associated with these side effects, were analyzed.Results: Ninety-five patients (8.3%), constituting 104 cases in total, experienced side effects. Although the frequency of drug reactions were increased from 0.6% at ages < 20 to 5.2% at ages 20-40, no gender or age differences were observed between patients who did and did not have side effects. White asymptomatic liver function disturbance was established in 56 of the patients (4.9%) with initiation of anti-TB therapy, the rate of hepatotoxicity was found to be 2.4% in this present study. No age or gender differences were observed among those who had hepatotoxicity and who had not. The major side effects were ototoxicity (1.7%), hepatotoxicity (0.8%), neuropsychiatric manifestations (0.7%), and hyperuricemia (0.6%).Conclusions: It must be remembered that severe side effects associated with anti-TB drugs were encountered with different frequencies especially among patients hospitalized for pulmonary tuberculosis, and these patients should be followed up by closer monitoring for side effects related to anti-TB drugs. (c) 2006 Elsevier Ltd. All rights reserved.