Contrasting effects of age on the plasma/whole blood lead ratio in men and women with a history of lead exposure
Contrasting effects of age on the plasma/whole blood lead ratio in men and women with a history of lead exposure
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DOI：
10.1016/j.envres.2006.03.007
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发表时间：
2006-09-01
影响因子：
8.3
通讯作者：
Tanus-Santos, Jose E.
中科院分区：
文献类型：
--
作者：
Barbosa, Fernando, Jr.;Ramires, Irene;Tanus-Santos, Jose E.
我们研究了年龄和性别对有铅暴露史的成年人群血铅（Pb-B）和血浆铅（Pb-P）浓度之间关系的影响。铅磷采用电感耦合等离子体质谱法（ICP-MS）测定，铅硼采用石墨炉原子吸收法（GF AAS）测定。我们研究了154名成年人（56名男性和98名女性），年龄从18岁到60岁。Pb-B水平从10.0到428.01 μ g/L不等，平均值为761 μ g/L。男性血铅水平为10.0 - 428.0 μ g/L（平均98.3 μ g/L），女性为10.0 - 263.0 μ g/L（平均62.8 μ g/L）。相应的Pb-Ps在男性和女性中分别为0.02-2.9 μ g/L（平均0.66 μ g/L）和0.02-1.5 μ g/L（平均0.42 μ g/L）。铅-硼与铅-磷呈曲线关系（r = 0.757，P < 0.001），符合斯皮尔曼相关。这两个量通过直线y = 0.0006x（1492）（y = Pb-P，x = Pb-B）相关联。%Pb-P/Pb-B比值范围为0.03%-1.85%。%Pb-P/Pb-B比值与Pb-B水平呈正相关。当数据按性别分开时，这种关联也与男性（y = 0.0184x（0-702））和女性（y = 0.0534x（0.5209））相关（y = %Pb-P/PbB和x = Pb-B）。此外，我们还发现Log（Pb-P/Pb-B）与年龄在女性中呈有趣的正相关（r = 0.31; P < 0.0001），而在男性中呈负相关（r =-0.164，P = 0.07）。综上所述，这些结果表明年龄对有铅暴露史的男性和女性的血浆/全血铅比值的影响存在差异。此外，性别可能在铅的代谢中起重要作用，这意味着进一步考虑铅毒性的动力学模型。(c)2006年爱思唯尔公司All rights reserved.
We examined the effect of age and sex on the relationship between the concentrations of Pb in blood (Pb-B) and in plasma (Pb-P) in an adult population with a history of lead exposure. Pb-P was determined by inductively coupled plasma mass spectrometry (ICP-MS) and Pb-B by graphite furnace atomic absorption spectrometry (GF AAS). We studied 154 adults (56 men and 98 women) from 18 to 60-year old. Pb-B levels varied from 10.0 to 428.01 mu g/L, with a mean of 761 mu g/L. Blood lead levels varied from 10.0 to 428.0 mu g/L in men (mean, 98.3 mu g/L) and from 10.0 to 263.0 mu g/L (mean, 62.8 mu g/L) in women. Corresponding Pb-Ps were 0.02-2.9 mu g/L (mean, 0.66 mu g/L) and 0.02-1.5 mu g/L (mean, 0.42 mu g/L) in men and women, respectively. The relationship between Pb-B and Pb-P was found to be curvilinear (r = 0.757, P < 0.001 Spearman's correlation). The two quantities are related by the line y = 0.0006x(1492) (y = Pb-P, and x = Pb-B). The %Pb-P/Pb-B ratio ranged from 0.03% to 1.85%. A positive association was found between %Pb-P/Pb-B ratio and Pb-B levels. When data were separated by sex, this association was also relevant for men (y = 0.0184x(0-702)) and women (y = 0.0534x(0.5209)) (y = %Pb-P/PbB and x = Pb-B). Moreover, we found an interesting positive correlation between Log (Pb-P/Pb-B) and age for women (r = 0.31; P < 0.0001) and a negative correlation for men (r = -0.164, P = 0.07). Taken together, these results suggest contrasting effects of age on the plasma/whole blood lead ratio in men and women with a history of lead exposure. Moreover, sex might play an important role in the metabolism of lead, implying further consideration on the kinetic models constructed of lead toxicity. (c) 2006 Elsevier Inc. All rights reserved.