The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study.
The Physiological Bases of Hidden Noise-Induced Hearing Loss: Protocol for a Functional Neuroimaging Study.
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DOI：
10.2196/resprot.9095
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发表时间：
2018-03-09
影响因子：
1.7
通讯作者：
Francis ST
中科院分区：
文献类型：
--
作者：
Dewey RS;Hall DA;Guest H;Prendergast G;Plack CJ;Francis ST
啮齿动物研究表明，噪声暴露会对内毛细胞和高阈值听觉神经纤维之间的突触造成永久性损伤，而不会永久改变阈值敏感性。这些通常被称为隐性听力损失的现象已在几种啮齿动物物种中得到证实，但其对人类听力的影响尚不清楚。我们的医学研究委员会资助的计划旨在通过调查终生累积噪声暴露对人类外周和中枢听觉神经系统造成的损害的功能后果来解决这个悬而未决的问题。行为和神经影像技术被用于一系列旨在检测人类隐性听力损失的平行研究。计划中的神经影像学研究旨在（1）识别与隐性听力损失相关的中枢听觉生物标志物； (2) 调查是否存在耳鸣或声音耐受性降低的附加影响，这些通常与听力问题共存； (3) 探讨皮层下功能磁共振成像 (fMRI) 测量与听觉脑干反应 (ABR) 之间的关系。年龄在 25 岁至 40 岁之间、纯音听力阈值在 500 Hz 至 8 kHz 范围内≤20 dB 听力水平且无 MRI 禁忌症或耳部疾病迹象的个体将被招募到研究中。将通过深入的结构化访谈来估计终生噪声暴露。将使用 ABR 和 fMRI 记录整个中央听觉系统的听觉反应。分析将主要关注终生噪声暴露与听觉反应特征之间的相关性。本文报告了研究方案。该资金于 2013 年 7 月授予。本协议中描述的研究招募于 2017 年 2 月开始，并于 2017 年 12 月完成。结果预计将于 2018 年得出。这项具有挑战性和全面的研究将有可能影响隐性听力损失的诊断程序，通过检测中枢听觉处理的变化，能够及早识别噪声引起的听觉损伤。因此，这将有机会提供有关耳部防护和监测进一步损害的个性化建议，从而减少噪音引起的听力损失的发生率。
Rodent studies indicate that noise exposure can cause permanent damage to synapses between inner hair cells and high-threshold auditory nerve fibers, without permanently altering threshold sensitivity. These demonstrations of what is commonly known as hidden hearing loss have been confirmed in several rodent species, but the implications for human hearing are unclear. Our Medical Research Council–funded program aims to address this unanswered question, by investigating functional consequences of the damage to the human peripheral and central auditory nervous system that results from cumulative lifetime noise exposure. Behavioral and neuroimaging techniques are being used in a series of parallel studies aimed at detecting hidden hearing loss in humans. The planned neuroimaging study aims to (1) identify central auditory biomarkers associated with hidden hearing loss; (2) investigate whether there are any additive contributions from tinnitus or diminished sound tolerance, which are often comorbid with hearing problems; and (3) explore the relation between subcortical functional magnetic resonance imaging (fMRI) measures and the auditory brainstem response (ABR). Individuals aged 25 to 40 years with pure tone hearing thresholds ≤20 dB hearing level over the range 500 Hz to 8 kHz and no contraindications for MRI or signs of ear disease will be recruited into the study. Lifetime noise exposure will be estimated using an in-depth structured interview. Auditory responses throughout the central auditory system will be recorded using ABR and fMRI. Analyses will focus predominantly on correlations between lifetime noise exposure and auditory response characteristics. This paper reports the study protocol. The funding was awarded in July 2013. Enrollment for the study described in this protocol commenced in February 2017 and was completed in December 2017. Results are expected in 2018. This challenging and comprehensive study will have the potential to impact diagnostic procedures for hidden hearing loss, enabling early identification of noise-induced auditory damage via the detection of changes in central auditory processing. Consequently, this will generate the opportunity to give personalized advice regarding provision of ear defense and monitoring of further damage, thus reducing the incidence of noise-induced hearing loss.