Solitary horizontal cells in culture--I. Their electrical properties.
Solitary horizontal cells in culture--I. Their electrical properties.
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培养中的孤立水平细胞--I．
DOI：
10.1016/0042-6989(83)90095-0
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发表时间：
1983
期刊：
影响因子：
1.8
通讯作者：
Tachibana,M
中科院分区：
文献类型：
--
作者：
Tachibana,M
在电流灯和电压灯条件下，研究了孤立水平电池的膜特性。静息膜电位主要由K离子决定。细胞产生全有或全无动作电位，并与内向和外向整流呈现出非线性的电流-电压关系。在电压钳条件下的药理和离子替代实验表明，离子电流至少分为四个分量：钙电流和三种类型的钾电流(通过反常整流的钾电流、瞬时外向电流和维持外向电流)。用这些离子电流解释了孤立水平电池的动作电位和非线性电流-电压关系。
Membrane properties of solitary horizontal cells were examined under current- and voltageclamp conditions. The resting membrane potential was mainly determined by K ions. The cells produced all-or-none action potentials and showed non-linear current-voltage relationships with inwardand outward-going rectification. Pharmacological and ion-substitution experiments under voltage-clamp conditions revealed that the ionic current was separated into at least four components; a Ca current and three types of K currents (a K current through an anomalous rectifier, a transient outward current, and a maintained outward current). The action potentials and the non-linear current-voltage relationships of solitary horizontal cells were explained from these ionic currents.