Chemoprevention for Colorectal Cancers: Are Chemopreventive Effects Different Between Left and Right Sided Colorectal Cancers?
Chemoprevention for Colorectal Cancers: Are Chemopreventive Effects Different Between Left and Right Sided Colorectal Cancers?
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结直肠癌的化学预防：左侧和右侧结直肠癌的化学预防效果是否不同？
DOI：
10.1007/s10620-022-07431-w
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发表时间：
2022
影响因子：
3.1
通讯作者：
Hayaka
中科院分区：
文献类型：
--
作者：
Arai Junya;Suzuki Nobumi;Niikura Ryota;Ooki Daisuke;Kawahara Takuya;Honda Tetsuro;Hasatani Kenkei;Yoshida Naohiro;Nishida Tsutomu;Sumiyoshi Tetsuya;Kiyotoki Shu;Ikeya Takashi;Arai Masahiro;Ishibashi Rei;Aoki Tomonori;Tsuji Yosuke;Yamamichi Nobutake;Hayaka
背景和目的最近的研究表明，右侧和左侧结直肠癌（CRC）是不同的分子。在这项研究中，我们检查了右侧和左侧CRC的风险与药物使用之间的关联，以估计其化学预防效果。方法这项多中心回顾性队列研究使用来自9家医院数据库的2014年至2019年住院患者的数据进行。主要结局是右侧和左侧CRC。我们评估了CRCs与药物使用和临床因素的关系。根据年龄、性别、Charlson合并症指数评分和吸烟状况调整比值比。我们还比较了癌前病变，包括无蒂锯齿状病变（SSLs）的转录谱。结果共有307,938例患者，包括2745例右侧CRC和4819例左侧CRC，进行了分析。使用非甾体抗炎药（NSAID）、阿司匹林、环氧合酶-2抑制剂和类固醇与右侧和左侧CRC的风险降低相关。相比之下，他汀类药物、其他降脂药物和二甲双胍与左侧CRC风险较低相关。转录组学分析表明，SSL，这主要是在右结肠的发展，与脂质代谢相关基因的表达较低。ConclusionsTargeting脂质代谢可能是有用的化学预防左侧CRC，而发展的右侧CRC可能是独立的这一途径。
Background and AimsRecent studies have suggested that right- and left-sided colorectal cancers (CRCs) are molecularly distinct. In this study, we examined the association between the risk of right- and left-sided CRC and drug use to estimate their chemopreventive effectsMethodsThis multicenter retrospective cohort study was conducted using the data of hospitalized patients between 2014 and 2019 from nine hospital databases. The primary outcomes were right- and left-sided CRC. We evaluated the association of CRCs with drug use and clinical factors. Odds ratios adjusted for age, sex, Charlson Comorbidity Index scores, and smoking status were calculated. We also compared the transcriptional profiling in precancerous lesions, including sessile serrated lesions (SSLs)ResultsA total of 307,938 patients, including 2745 with right-sided CRC and 4819 with left-sided CRC, were analyzed. The use of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, cyclooxygenase-2 inhibitors, and steroids was associated with a lower risk of both right- and left-sided CRCs. In contrast, statins, other lipid-lowering agents, and metformin were associated with a lower risk of left-sided CRC. Transcriptomic analysis showed that SSL, which predominantly develops in the right colon, was associated with a lower expression of lipid metabolism-related genes.ConclusionsTargeting lipid metabolism may be useful for chemoprevention of left-sided CRCs, while development of right-sided CRCs may be independent of this pathway.
影响因子：
6.4
作者：
Hoffmeister, Michael;Chang-Claude, Jenny;Brenner, Hermann
通讯作者：
Brenner, Hermann
影响因子：
10.3
作者：
Loupakis, Fotios;Yang, Dongyun;Lenz, Heinz-Josef
通讯作者：
Lenz, Heinz-Josef