New technique for high-throughput synthesis.

New technique for high-throughput synthesis.
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高通量合成新技术。

DOI:
10.1016/s0960-894x(99)00176-6
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发表时间:
1999
影响因子:
2.7
通讯作者:
Lebl,M
Lebl,M
中科院分区:
医学4区
文献类型:
--
作者:
Lebl,M

文献摘要

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描述了一种利用离心机从现成的标准微量滴定板上除去液体来进行高通量固相合成的新技术。该技术省去了过滤步骤,因此适用于同时处理无限数量的反应室。并以380个四氢异喹诺酮类化合物的合成为例说明了它的应用。
A new technique for high throughput solid phase synthesis using the centrifuge based liquid removal from readily available standard microtiterplates is described. This technique eliminates the filtration step and is therefore applicable to simultaneous processing of an unlimited number of reaction compartments. Its application is illustrated on the synthesis of an array of 380 tetrahydroisoquinolinones.