Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing
Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing
复制标题
离子液体功能化非释放抗菌水凝胶敷料联合电刺激促进糖尿病伤口愈合
DOI：
10.1016/j.cej.2021.129025
复制
发表时间：
2021-02-26
影响因子：
15.1
通讯作者：
Li, Chunya
中科院分区：
文献类型：
--
作者：
Liu, Pan;Jin, Kai;Li, Chunya
慢性创伤比一般创伤更难治愈，尤其是糖尿病患者的创伤。它还增加了细菌感染的风险，并可能导致其他严重的并发症。电刺激可以有效地促进伤口的愈合。然而，基于单个电极的ES策略难以覆盖整个受伤区域，这可能导致治疗效率不理想。本文报道了一种基于聚合离子液体和魔芋葡甘聚糖（KGM）的多功能导电水凝胶敷料。结果发现，这种新开发的水凝胶敷料不仅具有优异的机械性能和生物相容性，而且还提供了持久和有效的灭菌效果，而不会释放抗菌因子。使用该水凝胶敷料，随着电流电刺激的增强，成纤维细胞的迁移和增殖以及对糖尿病皮肤伤口的治疗效果显著提高。与ES偶联的聚合和离子液体官能化KGM水凝胶敷料可能能够提供有效治疗慢性伤口的新策略。
Chronic wounds are more difficult to be cured than the general wounds, particularly for the wounds of diabetic patients. It also increases the risk of bacterial infections and may cause other serious complications. Electrical stimulation (ES) can promote the healing of wounds efficiently. However, single electrode-based ES strategy is difficult to cover the entire part of the wounded area that may cause unsatisfactory treatment efficiency. We herein reported a multifunctional and conductive hydrogel dressing developed based on the polymerized ionic liquid and konjac glucomannan (KGM). It was found that this newly developed hydrogel dressing not only possesses excellent mechanical properties and biocompatibility but also provides a durable and efficient sterilization effect without releasing antibacterial factors. With the enhancement of current electrical stimulation by using this hydrogel dressing, the migration and proliferation of fibroblast cells and the treatment effect towards diabetic skin wounds were significantly improved. The polymerized and ionic liquid functionalized KGM hydrogel dressing coupled with ES may be able to provide a novel strategy for treating chronic wounds efficiently.