SENP1 regulates cell migration and invasion in neuroblastoma
SENP1 regulates cell migration and invasion in neuroblastoma
复制标题
SENP1 调节神经母细胞瘤中的细胞迁移和侵袭。
DOI：
10.1002/bab.1375
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发表时间：
2016-05-01
影响因子：
2.8
通讯作者：
Zhou Yun
中科院分区：
文献类型：
--
作者：
Yan Xiang-ming;Xu Zhi-qiang;Zhou Yun
神经母细胞瘤 (NB) 是一种源自交感神经系统前体细胞的胚胎实体瘤，占儿童癌症的 11% 和儿童癌症死亡的约 15%。 SUMOylation 和 deSUMOylation 是调节一系列蛋白质活性的动态机制。 SUMO 蛋白酶 (SENP) 可从蛋白质中去除 SUMO 缀合物，并且它们的表达在多种癌症中失调。然而，SENP 在 NBL 中的作用尚不清楚。在本研究中，我们发现与原发性NB组织相比，转移性NB组织中SENP1的表达显着高。 SENP1的过表达促进NB细胞的迁移和侵袭。抑制SENP1可以显着抑制NB细胞的迁移和侵袭。此外，我们发现SENP1可以调节CDH1、MMP9和MMP2的表达。总之，本文提供的数据表明 SENP1 在调节 NB 细胞迁移和侵袭中发挥重要作用，并抑制 SENP1 表达，是 NB 新型治疗策略的有希望的候选者。
Neuroblastoma (NB) is an embryonic solid tumor derived from precursor cells of the sympathetic nervous system, and accounts for 11% of childhood cancers and around 15% of cancer deaths in children. SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activities. The SUMO proteases (SENP) remove SUMO conjugate from proteins, and their expression is deregulated in diverse cancers. However, nothing is known about the role of SENPs in NBL. In the present study, we found that SENP1 expression was significantly high in metastatic NB tissues compared with primary NB tissues. Overexpression of SENP1 promoted NB cells migration and invasion. Inhibition of SENP1 could significantly suppress NB cell migration and invasion. Moreover, we found that SENP1 could regulate the expression of CDH1, MMP9, and MMP2. In summary, the data presented here indicate a significant role of SENP1 in the regulation of cell migration and invasion in NB and suppress SENP1 expression as promising candidates for novel treatment strategies of NB.