Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer
Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer
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DOI：
10.1093/jnci/dji039
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发表时间：
2005-02-16
期刊：
影响因子：
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通讯作者：
Giovannucci, E
中科院分区：
文献类型：
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作者：
Michels, KB;Willett, WC;Giovannucci, E
背景。在一些病例对照研究中，经常喝咖啡与降低结直肠癌的风险有关。队列研究尚未发现这种关联，但规模有限。我们在两组女性和男性的大型前瞻性队列中探讨了咖啡和茶的摄入量与结直肠癌发病率之间的关系。方法：我们使用来自护士健康研究（女性）和卫生专业人员随访研究（男性）的数据。1980年、1984年、1986年、1990年和1994年对女性和1986年、1990年和1994年对男性的咖啡和茶的消费量以及咖啡因的总摄入量进行了评估和更新。直到1998年，结肠癌和直肠癌的发病率才得以确定。使用Cox比例风险模型计算风险比，并对潜在混杂因素进行调整。所有具有统计学显著性的检验均为双侧检验。结果：在近200万人年的随访中，观察到1438例结直肠癌。在两个队列中，饮用含咖啡因的咖啡或茶或摄入咖啡因与结肠癌或直肠癌的发病率无关。对于这两个队列，每多喝一杯含咖啡因的咖啡，结直肠癌的协变量校正风险比为0.99（95%可信区间[CI] = 0.96至1.03）。然而,每天经常喝两杯或两杯以上脱咖啡因咖啡的参与者比从不喝脱咖啡因咖啡的参与者患直肠癌的几率低52% (95% CI = 19%至71%)（每天喝两杯或两杯以上脱咖啡因咖啡的参与者每10万人年随访中有12例直肠癌的粗发病率，而从不喝脱咖啡因咖啡的参与者每10万人年随访中有19例直肠癌的粗发病率）无咖啡因的咖啡)。结论：饮用含咖啡因的咖啡、含咖啡因的茶或咖啡因与结肠癌或直肠癌的发病率无关，而经常饮用不含咖啡因的咖啡与直肠癌的发病率降低有关。
Background. Frequent coffee consumption has been associated with a reduced risk of colorectal cancer in a number of case-control studies. Cohort studies have not revealed such an association but were limited in size. We explored the association between consumption of coffee and tea and the incidence of colorectal cancer in two large prospective cohorts of women and men.Methods: We used data from the Nurses' Health Study (women) and the Health Professionals' Followup Study (men). Consumption of coffee and tea and total caffeine intake were assessed and updated in 1980, 1984, 1986, 1990, and 1994 among women and in 1986, 1990, and 1994 among men. The incidence of cancer of the colon or rectum was ascertained through 1998. Hazard ratios were calculated using Cox proportional hazards models that adjusted for potential confounders. All tests of statistical significance were two-sided.Results: During almost 2 million person-years of follow-up, 1438 cases of colorectal cancer were observed. Consumption of caffeinated coffee or tea with caffeine or caffeine intake was not associated with the incidence of colon or rectal cancer in either cohort. For both cohorts combined, the covariate-adjusted hazard ratio for colorectal cancer associated with consumption of each additional cup of caffeinated coffee was 0.99 (95% confidence interval [CI] = 0.96 to 1.03). However, participants who regularly consumed two or more cups of decaffeinated coffee per day had a 52% (95% CI = 19% to 71%) lower incidence of rectal cancer than those who never consumed decaffeinated coffee (crude incidence rate of 12 cases of rectal cancer per 100000 person-years of follow-up among participants consuming two or more cups of decaffeinated coffee per day and crude incidence rate of 19 cases of rectal cancer per 100000 person-years of follow-up among participants who never consumed decaffeinated coffee).Conclusions: Consumption of caffeinated coffee, tea with caffeine, or caffeine was not associated with incidence of colon of rectal cancer, whereas regular consumption of decaffeinated coffee was associated with a reduced incidence of rectal cancer.