Deep Brain Recordings Using an Implanted Pulse Generator in Parkinson's Disease.
Deep Brain Recordings Using an Implanted Pulse Generator in Parkinson's Disease.
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DOI：
10.1111/ner.12348
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Kühn AA
中科院分区：
文献类型：
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作者：
Neumann WJ;Staub F;Horn A;Schanda J;Mueller J;Schneider GH;Brown P;Kühn AA
最近的研究表明，振荡β活性可用作帕金森病患者的状态生物标志物，用于丘脑底闭环刺激，旨在改善临床获益。在这里，我们调查的可行性底丘脑记录通过一种新的慢性植入脉冲发生器。在脑深部电刺激（DBS）之前和期间，从8名患者中获得丘脑底局部场电位记录。使用基于傅立叶变换的方法在频域中分析所有数据，并在开启和关闭刺激条件之间进行比较。在15个电极中的12个中发现了振荡β带活动的明显峰。DBS诱导振荡β活性的显著频率特异性抑制（p = 0.002）。该研究的结果表明，振荡β带同步和DBS对其的调制可以用适合于长期植入的系统记录，并且可以作为帕金森病患者的底丘脑闭环刺激的生物标志物。
Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson’s disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator. Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform based methods and compared between ON and OFF stimulation conditions. Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002). The results of the study suggest that oscillatory beta band synchronization and it’s modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson’s disease.