The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study
The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study
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单纯性打鼾与代谢综合征之间的关系：横断面研究
DOI：
10.1155/2019/9578391
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发表时间：
2019-01-01
影响因子：
4.3
通讯作者：
Yin, Shankai
中科院分区：
文献类型：
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作者：
Zou, Juanjuan;Song, Fan;Yin, Shankai
目的.这项横断面研究旨在评估单纯性打鼾与代谢综合征（MetS）之间的关系。方法.从2007年到2016年，共有5635名参与者，包括300名健康志愿者，据称没有打鼾。收集多导睡眠图变量、人体测量和生化指标。多项式线性趋势检验用于评估代谢评分的打鼾强度的线性趋势，logistic回归用于评估在控制年龄、性别、肥胖、吸烟状况和饮酒后MetS的比值比（OR）。结果最终研究人群包括866名参与者。单纯打鼾者比不打鼾者表现出更严重的代谢紊乱和更高的代谢综合征患病率。打鼾强度和代谢评分之间存在显著的线性趋势。在多变量调整后，所有参与者（OR=2.328，95%CI：1.340-4.045）和女性参与者（OR=2.382，95%CI：1.136-4.994）中，单纯打鼾与MetS风险增加显著相关。关于代谢综合征的成分，单纯打鼾与高血压的几率增加显著相关（OR=1.730，95%CI：1.130-2.650），腹型肥胖（OR=1.810，95%CI：1.063-3.083）和高甘油三酯（TG）（OR=1.814，95%CI：1.097-2.998），高血压组（OR=3.493，95%CI：1.748-6.979）经多变量调整后，女性中TG水平（OR=2.306，95%CI：1.245-4.270）和高TG水平（OR=2.803，95%CI：1.146-6.856）。结论.排除反复呼吸暂停和缺氧的影响后，单纯打鼾仍与代谢综合征显著相关，尤其是女性。此外，男性高血压和女性腹型肥胖与高TG的相关性更明显。除了OSA，单纯性打鼾也应该重视。
Purpose. This cross-sectional study was performed to assess the relationship between simple snoring and metabolic syndrome (MetS). Methods. A total of 5635 participants including 300 healthy volunteers without snoring allegedly were initially included from 2007 to 2016. Polysomnographic variables, anthropometric measurements, and biochemical indicators were collected. The polynomial linear trend test was used to assess the linear trend across snoring intensity for metabolic score, and logistic regression was used to evaluate the odds ratios (ORs) for MetS after controlling for age, sex, obesity, smoking status, and alcohol consumption. Results. The final study population consisted of 866 participants. Simple snorers showed more severe metabolic disorders and higher prevalence of MetS than nonsnorers. A significant linear trend was observed between snoring intensity and metabolic score. Simple snoring was significantly associated with increased odds for MetS among all participants (OR=2.328, 95% CI: 1.340-4.045) and female participants (OR=2.382, 95% CI: 1.136-4.994) after multivariable adjustment. With regard to MetS components, simple snoring was significantly associated with increased odds for hypertension (OR=1.730, 95% CI: 1.130-2.650), abdominal obesity (OR=1.810, 95% CI: 1.063-3.083), and hyper-triglycerides (TG) (OR=1.814, 95% CI: 1.097-2.998) among all participants, with hypertension (OR=3.493, 95% CI: 1.748-6.979) among males and with abdominal obesity (OR=2.306, 95% CI: 1.245-4.270) and hyper-TG (OR=2.803, 95% CI: 1.146-6.856) among females after multivariable adjustment. Conclusions. After excluding the influence of repeated apnea and hypoxia, simple snoring was still significantly associated with MetS, especially in women. Furthermore, the associations were more obvious for hypertension among males and for abdominal obesity and hyper-TG among females. In addition to OSA, simple snoring also should be valued.