Sick individuals and sick populations
Sick individuals and sick populations
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DOI：
10.1093/ije/30.3.427
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发表时间：
2001-06-01
影响因子：
7.7
通讯作者：
Rose, G
中科院分区：
文献类型：
--
作者：
Rose, G
病因学面临两个不同的问题：个体病例的决定因素和发病率的决定因素。如果人群中某种必要药物的暴露是同质的，那么病例/对照和队列方法将无法检测到它：它们只能识别易感性标记。相应的控制策略是“高风险”方法，旨在保护易感个体，以及群体方法，旨在控制发病原因。这两种方法通常不存在竞争，但优先考虑的始终是发现和控制发生的原因。
Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding strategies in control are the 'high-risk' approach, which seeks to protect susceptible individuals, and the population approach, which seeks to control the causes of incidence. The two approaches are not usually in competition, but the prior concern should always be to discover and control the causes of incidence.