Medication noncompliance and substance abuse among patients with schizophrenia.
Medication noncompliance and substance abuse among patients with schizophrenia.
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DOI：
10.1176/ps.47.8.853
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发表时间：
1996-08
影响因子：
3.8
通讯作者：
R. Owen;E. Fischer;B. Booth;B. Cuffel
中科院分区：
文献类型：
--
作者：
R. Owen;E. Fischer;B. Booth;B. Cuffel
目的探讨精神分裂症患者服药不依从和物质滥用对症状的影响。方法短期住院的精神分裂症患者被纳入一项纵向结果研究，出院后继续接受标准护理。在基线和6个月随访时，获得简明精神病评定量表（BPRS）评分和受试者报告的药物依从性、药物和酒精滥用、日常生活安排和观察到的副作用的数据。从病历中获得随访期间的门诊接触人数。使用逻辑回归和线性回归模型分析因变量（服药不依从性和随访BPRS评分）与自变量之间的关系。结果药物不依从与药物滥用显著相关。滥用药物、无门诊接触、不依从药物治疗的受试者的症状严重程度显著高于其他组。结论精神分裂症患者药物滥用与药物治疗不依从性密切相关。药物滥用、药物不依从和缺乏门诊接触的组合似乎定义了一个特别高的风险群体。
OBJECTIVE The study examined the effect of medication noncompliance and substance abuse on symptoms of schizophrenia. METHODS Short-term inpatients with a diagnosis of schizophrenia were enrolled in a longitudinal outcomes study and continued to receive standard care after discharge. At baseline and six-month follow-up, Brief Psychiatric Rating Scale (BPRS) scores and data on subjects' reported medication compliance, drug and alcohol abuse, usual living arrangements, and observed side effects were obtained. The number of outpatient contacts during the follow-up period was obtained from medical records. Relationships between the dependent variables-medication noncompliance and follow-up BPRS scores-and the independent variables were analyzed using logistic and linear regression models. RESULTS Medication noncompliance was significantly associated with substance abuse. Subjects who abused substances, had no outpatient contact, and were noncompliant with medication had significantly greater symptom severity than other groups. CONCLUSIONS Substance abuse is strongly associated with medication noncompliance among patients with schizophrenia. The combination of substance abuse, medication noncompliance, and lack of outpatient contact appears to define a particularly high-risk group.