NON-INVASIVE DETERMINATION OF LOCAL CEREBRAL METABOLIC-RATE OF GLUCOSE IN MAN
NON-INVASIVE DETERMINATION OF LOCAL CEREBRAL METABOLIC-RATE OF GLUCOSE IN MAN
复制标题
DOI：
10.1152/ajpendo.1980.238.1.e69
复制
发表时间：
1980-01-01
影响因子：
--
通讯作者：
KUHL, DE
中科院分区：
文献类型：
--
作者：
HUANG, SC;PHELPS, ME;KUHL, DE
本文介绍了一种测定正常人局部脑葡萄糖代谢率（LCMRGlc）的方法。该方法采用[18 F]2-氟-2-脱氧-D-葡萄糖（FDG）和发射型计算机断层扫描（ECT）。静脉推注FDG。用ECT测量不同脑区的放射性。从血液样品测量注射后的血浆FDG浓度。采用描述FDG转运动力学的数学模型来确定FDG的转运速率常数，并将放射性测量值转换为代谢率。该模型考虑了脑组织中FDG-6-PO 4（FDG-6-P）可能发生的去磷酸化反应，生成游离FDG。实验在13名正常志愿者中进行。人的FDG的速率常数与大鼠和恒河猴的脱氧葡萄糖的速率常数相当。灰质和白色物质中的平均LCMRG 1c为7.30 ± 0.001。1.18（SD）和3.41 . ±-。0.64 mg/min/100 g脑组织。通过本方法测量的LCMRG 1c的受试者间变化与测量全脑CMRG 1c的其他方法的受试者间变化相当。
A method for the determination of local cerebral metabolic rates of glucose (LCMRGlc) in normal man is described. The method employs [18F]2-fluoro-2-deoxy-D-glucose (FDG) and emission-computed tomography (ECT). FDG was i.v. injected as a bolus. Radioactivities in separate brain regions were measured with ECT. Plasma FDG concentration following injection was measured from blood samples. A mathematical model that describes the kinetics of FDG transports was employed to determine the transport rate constants of FDG and to convert the radioactivity measurements to metabolic rates. The model has taken into account the possible dephosphorylation reaction from FDG-6-PO4 (FDG-6-P) to free FDG in brain tissues. Experiments were performed in 13 normal volunteers. The rate constants of FDG in man were comparable to those of deoxyglucose in rat and in rhesus monkey. The average LCMRGlc in gray and in white matter were 7.30 .+-. 1.18 (SD) and 3.41 .+-. 0.64 mg/min per 100 g brain tissue, respectively. The subject-to-subject variation of LCMRGlc as measured by the present method was comparable to those of other methods that measure whole-brain CMRGlc.