Amine-catalyzed (3+n) annulations of 2-(acetoxymethyl)buta-2,3-dienoates with 1,n-bisnucleophiles (n = 3-5).
Amine-catalyzed (3+n) annulations of 2-(acetoxymethyl)buta-2,3-dienoates with 1,n-bisnucleophiles (n = 3-5).
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DOI：
10.1039/c0cc01966f
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发表时间：
2010-10
影响因子：
4.9
通讯作者：
Chaolong Li;Q. Zhang;Xiaofeng Tong
中科院分区：
文献类型：
--
作者：
Chaolong Li;Q. Zhang;Xiaofeng Tong
本文报道了叔胺催化的2-（乙酰氧基甲基）-2，3-丁二烯酸酯与1，n-二亲核试剂的（3+n）缩甲醛成环反应。并建立了串联的S（N）2 ′-S（N）2 ′取代和Michael加成的反应机理。
A tertiary amine-catalyzed formal (3+n) annulation of 2-(acetoxymethyl)buta-2,3-dienoate with 1,n-binucleophiles has been developed, which provides a facile entry to heterocyclic compounds. The mechanism, involving tandem S(N)2'-S(N)2' substitution and Michael addition, has also been established.