EVIDENCE THAT ADENOSINE TRIPHOSPHATE OR A RELATED NUCLEOTIDE IS TRANSMITTER SUBSTANCE RELEASED BY ONO-ADRENERGIC INHIBITORY NERVES IN GUT
EVIDENCE THAT ADENOSINE TRIPHOSPHATE OR A RELATED NUCLEOTIDE IS TRANSMITTER SUBSTANCE RELEASED BY ONO-ADRENERGIC INHIBITORY NERVES IN GUT
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DOI：
10.1111/j.1476-5381.1970.tb10646.x
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发表时间：
1970-01-01
影响因子：
7.3
通讯作者：
SMYTHE, A
中科院分区：
文献类型：
--
作者：
BURNSTOCK, G;CAMPBELL, G;SMYTHE, A
1.刺激迷走神经的非肾上腺素能抑制神经，可使腺苷和肌苷从豚鼠和蟾蜍的胃血管灌流液中释放出来。2.刺激分离自火鸡肌胃的部分奥尔巴赫神经丛，引起三磷酸腺苷(ATP)、二磷酸腺苷(ADP)和一磷酸腺苷(AMP)的释放。3.将三磷酸腺苷加入通过蟾蜍胃血管系统灌流的溶液中，将其分解为腺苷、肌苷和腺嘌呤。4.在一系列嘌呤和嘧啶类化合物对豚鼠结肠带绦虫的抑制作用中，以三磷酸腺苷和二磷酸腺苷最强。5.三磷酸腺苷对其他12种肠道制剂有抑制作用，这些肠道制剂以前被证明含有非肾上腺素能抑制神经。河豚毒素不能阻断ATP的抑制作用。6.奎尼丁拮抗儿茶酚胺或肾上腺素能神经刺激对豚鼠结肠带的松弛作用。高浓度的奎尼丁可拮抗三磷酸腺苷或非肾上腺素能抑制性神经刺激引起的松弛。7.当兔回肠产生对三磷酸腺苷的快速反应时，对非肾上腺素能抑制神经刺激的反应持续抑制，而对肾上腺素能神经刺激的反应不受抑制。8.提示三磷酸腺苷或相关核苷酸是肠道非肾上腺素能抑制性神经支配释放的递质。图片
1. Stimulation of the vagal non-adrenergic inhibitory innervation caused the release of adenosine and inosine into vascular perfusates from the stomachs of guinea-pigs and toads. 2. Stimulation of portions of Auerbach's plexus isolated from turkey gizzard caused the release of adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP). 3. ATP, added to solutions perfused through the toad stomach vasculature, was broken down to adenosine, inosine and adenine. 4. Of a series of purine and pyrimidine derivatives tested for inhibitory activity on the guinea-pig isolated taenia coli, ATP and ADP were the most potent. 5. ATP caused inhibition of twelve other gut preparations previously shown to contain non-adrenergic inhibitory nerves. The inhibitory action of ATP was not prevented by tetrodotoxin. 6. Quinidine antagonized relaxations of the guinea-pig taenia coli caused by catecholamines or adrenergic nerve stimulation. Higher concentrations of quinidine antagonized relaxations caused by ATP or non-adrenergic inhibitory nerve stimulation. 7. When tachyphylaxis to ATP had been produced in the rabbit ileum, there was a consistent depression of the responses to non-adrenergic inhibitory nerve stimulation but not of responses to adrenergic nerve stimulation. 8. It is suggested that ATP or a related nucleotide is the transmitter substance released by the non-adrenergic inhibitory innervation of the gut. Images