Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria
Functional Synergy between Antimicrobial Peptoids and Peptides against Gram-Negative Bacteria
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DOI：
10.1128/aac.00578-11
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发表时间：
2011-11-01
影响因子：
4.9
通讯作者：
Barron, Annelise E.
中科院分区：
文献类型：
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作者：
Chongsiriwatana, Nathaniel P.;Wetzler, Modi;Barron, Annelise E.
抗菌肽（AMP）是先天免疫的组成部分，通常以组合形式存在，其中它们可以协同产生更广谱或更有效的活性。以前，我们报道了具有强效和选择性抗微生物活性的AMP的类肽模拟物。使用棋盘格测定，我们证明，类肽和AMP可以相互作用协同，分数抑制浓度指数低至0.16。这些结果强烈表明，抗微生物类肽和肽在功能和机制上是类似的。
Antimicrobial peptides (AMPs) are integral components of innate immunity and are typically found in combinations in which they can synergize for broader-spectrum or more potent activity. Previously, we reported peptoid mimics of AMPs with potent and selective antimicrobial activity. Using checkerboard assays, we demonstrate that peptoids and AMPs can interact synergistically, with fractional inhibitory concentration indices as low as 0.16. These results strongly suggest that antimicrobial peptoids and peptides are functionally and mechanistically analogous.