MILD COGNITIVE IMPAIRMENT IN THE ELDERLY - PREDICTORS OF DEMENTIA
MILD COGNITIVE IMPAIRMENT IN THE ELDERLY - PREDICTORS OF DEMENTIA
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DOI：
10.1212/wnl.41.7.1006
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发表时间：
1991-07-01
期刊：
影响因子：
9.9
通讯作者：
REISBERG, B
中科院分区：
文献类型：
--
作者：
FLICKER, C;FERRIS, SH;REISBERG, B
我们对32名临床确诊为轻度认知障碍的老年受试者和32名年龄匹配、受教育程度匹配的正常受试者进行了全面的诊断评估，包括综合认知评估组合。轻度受损的受试者在近期记忆、远距离记忆、语言功能、概念形成和视觉空间练习的测试中的表现明显低于对照组。两年后对认知状态的随访评估显示，在23名(72%)轻度受损受试者中，临床上可以检测到相对于基线的认知能力下降。一些客观的心理测试在基线上准确地区分了轻度受损组中下降和不下降的人。在20名没有复杂情况的轻度受损受试者中，16人在基线和随访期间表现出认知能力下降。这些结果表明，大多数由临床评估和客观心理测试确定的轻度认知障碍的老年受试者将表现出痴呆症的进行性智力恶化的特征，心理测量学预测因子可以用于区分轻度受损的老年受试者的良性和更严重的潜在疾病。
We conducted full diagnostic evaluations, including a comprehensive cognitive assessment battery, of a group of 32 elderly subjects with a clinically identified mild cognitive impairment and a group of 32 age-matched and education-matched normal subjects. The mildly impaired subjects performed significantly more poorly than the controls on tests of recent memory, remote memory, language function, concept formation, and visuospatial praxis. Follow-up evaluations of cognitive status 2 years later revealed clinically detectable cognitive decline relative to baseline in 23 (72%) of the mildly impaired subjects. Several of the objective psychological tests accurately discriminated at baseline between the decliners and nondecliners in the mildly impaired group. Among the 20 mildly impaired subjects with no complicating conditions, 16 exhibited cognitive deterioration between baseline and follow-up. These results suggest that most elderly subjects with mild cognitive deficits, as determined by clinical evaluation and objective psychological testing, will manifest the progressive mental deterioration characteristic of dementia and that psychometric predictors can be used to distinguish between benign and more significant underlying disorders in mildly impaired elderly subjects.