Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
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DOI：
10.1038/ni.3213
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发表时间：
2015-08-01
影响因子：
30.5
通讯作者：
Pabst, Oliver
中科院分区：
文献类型：
--
作者：
Lindner, Cornelia;Thomsen, Irene;Pabst, Oliver
分泌型免疫球蛋白A（SIgA）保护肠上皮免受腔抗原的侵害，并有助于宿主-微生物共生。然而，如何调节抗体反应以实现持续的宿主-微生物相互作用尚不清楚。我们发现，尽管在抗生素治疗或感染期间微生物群发生了重大变化，但小鼠和人类在伊加库中表现出克隆相关B细胞的纵向持久性。记忆B细胞之间的诱导室循环，并在肠道和乳腺中的浆细胞克隆相关。我们的研究结果表明，记忆B细胞的持续多样化构成了建立共生宿主-微生物相互作用的中心过程，并解释了母体抗体如何在整个生命过程中优化以保护新生儿。
Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn.