Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects
Transcranial Direct Current Stimulation and Cerebral Vasomotor Reserve: A Study in Healthy Subjects
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DOI：
10.1111/jon.12162
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发表时间：
2015-07-01
影响因子：
2.4
通讯作者：
Sartucci, Ferdinando
中科院分区：
文献类型：
--
作者：
Giorli, Elisa;Tognazzi, Silvia;Sartucci, Ferdinando
背景与目的脑血管舒缩储备（VMR）是脑小动脉在各种刺激（如高碳酸血症）下改变其直径的能力。经颅直流电刺激（tDCS）引起的VMR变化研究甚少。方法对25名健康受试者进行右初级运动区阳极/阴极和假性tDCS。在tDCS前后，我们通过经颅彩色编码超声（TCCS）计算呼吸保持指数（BHI）和心率变异性（HRV）来评估VMR，特别是在Valsalva操作后。结果sa - tdcs降低VMR和BHI (p < 0.05)， C-tDCS提高VMR和BHI (p < 0.05)；Sham的VMR、BHI和HRV均无统计学意义（p < 0.05）。结论本研究证实tDCS诱导双侧VMR的改变具有极性特异性效应；基于这种双边MFV和BHI的修改，我们可以推测SNS参与了VMR监管。
BACKGROUND AND PURPOSECerebral vasomotor reserve (VMR) is the capability of cerebral arterioles to change their diameter in response to various stimuli, such hypercapnia. Changes of VMR due to transcranial direct current stimulation (tDCS) have been poorly studied.METHODSTwenty-five healthy subjects underwent anodal/cathodal and sham tDCS on right primary motor area. Before and after tDCS, we assessed VMR by Transcranial Color-Coded Sonography (TCCS) calculating trought Breath Holding Index (BHI) and Heart Rate Variability (HRV), in particular after Valsalva manouver.RESULTSA-tDCS decreased VMR and BHI (p < 0.05), whereas C-tDCS increased VMR, and BHI (p < 0.05); Sham doesn't provide statistically significant of both VMR, BHI and HRV (p > 0.05).CONCLUSIONSOur study confirms that tDCS induces a modification of bilateral VMR with a polarity-specific effect; based on this bilateral MFV and BHI modifications, we can speculate an involvement of the SNS in the VMR regulation.