Role of Peripheral Immune Cells for Development and Recovery of Chronic Pain.
Role of Peripheral Immune Cells for Development and Recovery of Chronic Pain.
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外周免疫细胞在慢性疼痛发生和恢复中的作用。
DOI：
10.3389/fimmu.2021.641588
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发表时间：
2021
影响因子：
7.3
通讯作者：
Fischer R
中科院分区：
文献类型：
--
作者：
Bethea JR;Fischer R
慢性神经病理性疼痛(CNP)是由躯体感觉神经系统的病变或疾病引起的。它影响了大约8%的总人口，并对一个人的功能水平和生活质量产生了负面影响。它对现有止痛疗法的抵抗力使CNP成为一种主要的未得到满足的医疗需求。免疫细胞已被证明在CNP的发生、维持和恢复中发挥作用，因此是新的疼痛治疗的有吸引力的靶点。特别是，在神经病理性的小鼠和人类中，小胶质细胞在背角被激活，外周免疫细胞渗透到神经系统，促进慢性神经炎，并在CNP的发生和发展中发挥作用。重要的是，免疫不仅控制疼痛的发展和维持，而且对疼痛的解决也是必不可少的。特别是，调节性T细胞、具有免疫调节功能的T淋巴细胞亚群和巨噬细胞被证明是疼痛恢复的重要贡献者。在这篇综述中，我们总结了外周免疫系统与神经系统的相互作用，并概述了它们在疼痛的发展和恢复中的作用。
Chronic neuropathic pain (CNP) is caused by a lesion or disease of the somatosensory nervous system. It affects ~8% of the general population and negatively impacts a person's level of functioning and quality of life. Its resistance to available pain therapies makes CNP a major unmet medical need. Immune cells have been shown to play a role for development, maintenance and recovery of CNP and therefore are attractive targets for novel pain therapies. In particular, in neuropathic mice and humans, microglia are activated in the dorsal horn and peripheral immune cells infiltrate the nervous system to promote chronic neuroinflammation and contribute to the initiation and progression of CNP. Importantly, immunity not only controls pain development and maintenance, but is also essential for pain resolution. In particular, regulatory T cells, a subpopulation of T lymphocytes with immune regulatory function, and macrophages were shown to be important contributors to pain recovery. In this review we summarize the interactions of the peripheral immune system with the nervous system and outline their contribution to the development and recovery of pain.
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DOI：
10.1084/jem.20151563
发表时间：
2016-08-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chopra M;Biehl M;Steinfatt T;Brandl A;Kums J;Amich J;Vaeth M;Kuen J;Holtappels R;Podlech J;Mottok A;Kraus S;Jordán-Garrote AL;Bäuerlein CA;Brede C;Ribechini E;Fick A;Seher A;Polz J;Ottmüller KJ;Baker J;Nishikii H;Ritz M;Mattenheimer K;Schwinn S;Winter T;Schäfer V;Krappmann S;Einsele H;Müller TD;Reddehase MJ;Lutz MB;Männel DN;Berberich-Siebelt F;Wajant H;Beilhack A
通讯作者：
Beilhack A
影响因子：
25
作者：
Dombrowski Y;O'Hagan T;Dittmer M;Penalva R;Mayoral SR;Bankhead P;Fleville S;Eleftheriadis G;Zhao C;Naughton M;Hassan R;Moffat J;Falconer J;Boyd A;Hamilton P;Allen IV;Kissenpfennig A;Moynagh PN;Evergren E;Perbal B;Williams AC;Ingram RJ;Chan JR;Franklin RJM;Fitzgerald DC
通讯作者：
Fitzgerald DC
影响因子：
5.3
作者：
Duffy, Samuel S.;Keating, Brooke A.;Moalem-Taylor, Gila
通讯作者：
Moalem-Taylor, Gila
影响因子：
81.5
作者：
Colloca, Luana;Ludman, Taylor;Raja, Srinivasa N.
通讯作者：
Raja, Srinivasa N.
DOI：
10.1073/pnas.1605195113
发表时间：
2016-10-25
影响因子：
11.1
作者：
Dong, Yun;Fischer, Roman;Eisel, Ulrich L. M.
通讯作者：
Eisel, Ulrich L. M.