Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women
Correlation between estrogens and serum adipocytokines in premenopausal and postmenopausal women
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DOI：
10.1097/gme.0b013e31802cddca
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Kim, Sun Haeng
中科院分区：
文献类型：
--
作者：
Hong, Soon Cheol;Yoo, Sang Wook;Kim, Sun Haeng
目的：本研究的目的是探讨血清脂肪细胞因子之间的关系，（脂联素、瘦素、肿瘤坏死因子α [TNF-α]）和内源性雌激素健康绝经前和绝经后妇女的雌酮和雌二醇水平。设计：该研究包括53名健康绝经前妇女，45名健康绝经后妇女，和10名绝经后代谢综合征妇女参加一般健康检查。对脂联素、瘦素、TNF-α、雌酮（E-1）和雌二醇（E-2）的水平进行二次分析。考虑体重指数后，TNF-α显著升高（1.5 +/- 0.1 vs 2.0 +/- 0.1 pg/mL，P < 0.05），而瘦素降低（5.6 +/- 1.1 vs 4.0 +/- 1.1 ng/mL）。雌激素（E-1和E-2）与瘦素仅在健康的绝经前妇女呈正相关，而雌激素与任何脂肪细胞因子在健康的绝经后妇女。在多元回归分析中，只有瘦素对胰岛素抵抗有显著影响。健康绝经前后妇女血清E1水平与TNF-α呈负相关（r =-0.23，P < 0.05），与瘦素呈正相关（r = 0.35，P < 0.01），而与血清瘦素无相关性。E-2与TNF-α呈负相关（r =-0.24，P < 0.05），与leptin呈正相关（r = 0.34，P < 0.01），与脂联素、瘦素无相关性。瘦素可能刺激血浆促性腺激素释放激素水平的升高，这可能导致在绝经前妇女，而不是在绝经后妇女的雌激素呈正相关。结论：雌激素缺乏导致TNF-α水平升高。绝经前妇女血清瘦素水平与雌激素水平呈正相关。然而，绝经后妇女肥胖的增加增加了瘦素，从而增加了胰岛素抵抗。
Objective: The purpose of this study was to investigate the association between serum adipocytokines (adiponectin, resistin, leptin, and tumor necrosis factor alpha [TNF-alpha]) and endogenous estrogen (estrone and estradiol) levels in healthy premenopausal and postmenopausal women.Design: This study included 53 healthy premenopausal women, 45 healthy postmenopausal women, and 10 postmenopausal women with the metabolic syndrome who were participating in general health examinations. A secondary analysis was performed on levels of adiponectin, resistin, leptin, TNF-ot, estrone (E-1), and estradiol (E-2).Results: After accounting for body mass index, TNF-ot was significantly increased (1.5 +/- 0.1 vs 2.0 +/- 0.1 pg/mL, P < 0.05) in healthy postmenopausal women as compared with healthy premenopausal women, whereas leptin was decreased (5.6 +/- 1.1 vs 4.0 +/- 1.1 ng/mL). Estrogen (E-1 and E-2) was positively correlated with leptin in only healthy premenopausal women, whereas estrogen did not correlate with any adipocytokine in healthy postmenopausal women. In the multiple regression analysis, only leptin significantly contributed to insulin resistance. Combining healthy premenopausal and postmenopausal women, El correlated negatively with TNF-alpha (r = -0.23, P < 0.05) and positively with leptin (r = 0.35, P < 0.01) and did not correlate with resistin. E-2 correlated negatively with TNF-alpha (r = -0.24, P < 0.05) and positively with leptin (r = 0.34, P < 0.01); it did not correlate with adiponectin or resistin. Leptin might stimulate the increase of plasma gonadotropin-releasing hormone levels, which could result in a positive correlation with estrogen in premenopausal women but not in postmenopausal women.Conclusions: Estrogen deficiency resulted in increased TNF-ot levels. Serum leptin levels correlated positively with estrogen levels in premenopausal women. However, the increase in obesity in postmenopausal women increased leptin, which increases insulin resistance.