Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma.
Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma.
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DOI：
10.1186/s13045-016-0278-x
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发表时间：
2016-06-03
影响因子：
28.5
通讯作者：
Bhadri VA
中科院分区：
文献类型：
--
作者：
McCaughan GJ;Fulham MJ;Mahar A;Soper J;Hong AM;Stalley PD;Tattersall MH;Bhadri VA
尤文肉瘤（EWS）是一种骨和软组织的恶性肿瘤，尽管许多患者可以通过常规的多模式治疗治愈，但复发或转移性疾病的患者预后不良。已在EWS中确定了基因组不稳定性和程序性细胞死亡配体-1（PD-L1）表达，为使用阻断程序性细胞死亡-1（PD-1）受体的药物进行治疗提供了依据。在这份报告中，我们描述了一个大量的预先治疗的复发性转移性EWS患者谁实现了临床和放射学缓解与PD-1封锁。据我们所知，这是第一例证明PD-1阻断剂在EWS中有效的报告病例。考虑到复发性或转移性疾病患者的预后不良，这需要进一步研究。
Ewing sarcoma (EWS) is a malignant tumour of bone and soft tissue, and although many patients are cured with conventional multimodal therapy, those with recurrent or metastatic disease have a poor prognosis. Genomic instability and programmed cell death ligand-1 (PD-L1) expression have been identified in EWS, providing a rationale for treatment with agents that block the programmed cell death-1 (PD-1) receptor. In this report, we describe a heavily pre-treated patient with recurrent metastatic EWS who achieved a clinical and radiological remission with PD-1 blockade. To our knowledge, this is the first reported case demonstrating efficacy of PD-1 blockade in EWS. This warrants further investigation in particular given the poor prognosis in patients with recurrent or metastatic disease.