6‐(2,6‐Dichlorobenzyl)‐5‐ethyl‐2‐(4‐methoxybenzylsulfanyl)pyrimidin‐4(3H)‐one
6‐(2,6‐Dichlorobenzyl)‐5‐ethyl‐2‐(4‐methoxybenzylsulfanyl)pyrimidin‐4(3H)‐one
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DOI：
10.1107/s1600536807034976
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发表时间：
2007-08
影响因子：
0.9
通讯作者：
Yueping Wang;Fen‐er Chen;Minqin Chen
中科院分区：
文献类型：
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作者：
Yueping Wang;Fen‐er Chen;Minqin Chen
标题化合物C21H20Cl2N2O2S被合成为人类免疫缺陷病毒1型(HIV-1)的潜在逆转录酶(RT)抑制剂。结构分析证实该化合物以~3H-互变异构体形式存在。晶体结构中通过N-H⋯O氢键对形成中心对称二聚体。该结构还表现为C-H⋯Cl和C-H⋯O相互作用。
The title compound, C21H20Cl2N2O2S, was synthesized as a potential reverse transcriptase (RT) inhibitor of the human immunodeficiency virus type 1 (HIV-1). Structural analysis confirms that the compound is present in the 3H-tautomeric form. A centrosymmetric dimer is formed in the crystal structure through pairs of N—H⋯O hydrogen bonds. The structure also displays C—H⋯Cl and C—H⋯O interactions.