MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry-Standardization of Nomenclature
MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry-Standardization of Nomenclature
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DOI：
10.2967/jnumed.108.056036
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发表时间：
2009-03-01
影响因子：
9.3
通讯作者：
Thomas, Stephen R.
中科院分区：
文献类型：
--
作者：
Bolch, Wesley E.;Eckerman, Keith F.;Thomas, Stephen R.
核医学学会医学内部辐射剂量（MIRD）委员会的内部剂量计方案为评估整个器官、组织亚区、体素化组织结构和单个细胞区室的吸收剂量提供了一个广泛的框架，用于诊断和治疗核医学。该图式最初于1968年出版，1976年修订，并于1988年和1991年以教学形式重新出版，其中包括作为MIRD入门的综合示例。国际放射防护委员会（ICRP）也是一个提供剂量学模型和技术数据的组织，用于就工人和一般公众接触电离辐射的限度提出建议。ICRP制定了一套与MIRD委员会类似的剂量学方案，但对吸收分数、特定吸收分数和各种剂量系数等基本量使用了不同的术语和符号。辐射剂量评估委员会编写本手册的目标有三个方面：以符合核医学和辐射防护界需要的方式重申其吸收剂量评估方案，目标是使命名标准化；正式采用剂量学量、等效剂量和有效剂量，用于核医学手术后患者辐射随机效应潜在风险的比较评价；并讨论确定基于吸收剂量的剂量测定量的必要性，以解决与靶向放射性核素治疗有关的确定性效应。
The internal dosimetry schema of the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine has provided a broad framework for assessment of the absorbed dose to whole organs, tissue subregions, voxelized tissue structures, and individual cellular compartments for use in both diagnostic and therapeutic nuclear medicine. The schema was originally published in 1968, revised in 1976, and republished in didactic form with comprehensive examples as the MIRD primer in 1988 and 1991. The International Commission on Radiological Protection (ICRP) is an organization that also supplies dosimetric models and technical data, for use in providing recommendations for limits on ionizing radiation exposure to workers and members of the general public. The ICRP has developed a dosimetry schema similar to that of the MIRD Committee but has used different terminology and symbols for fundamental quantities such as the absorbed fraction, specific absorbed fraction, and various dose coefficients. The MIRD Committee objectives for this pamphlet are 3-fold: to restate its schema for assessment of absorbed dose in a manner consistent with the needs of both the nuclear medicine and the radiation protection communities, with the goal of standardizing nomenclature; to formally adopt the dosimetry quantities equivalent dose and effective dose for use in comparative evaluations of potential risks of radiation-induced stochastic effects to patients after nuclear medicine procedures; and to discuss the need to identify dosimetry quantities based on absorbed dose that address deterministic effects relevant to targeted radionuclide therapy.