The continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma - A surveillance, epidemiology, and end results analysis
The continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma - A surveillance, epidemiology, and end results analysis
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DOI：
10.1002/cncr.10851
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发表时间：
2002-10-01
期刊：
影响因子：
6.2
通讯作者：
O'Neill, BP
中科院分区：
文献类型：
--
作者：
Olson, JE;Janney, CA;O'Neill, BP
背景。原发性中枢神经系统淋巴瘤（PCNSL）是一种结外形式的非霍奇金淋巴瘤，起源于颅脊髓轴。PCNSL的发病率呈上升趋势。1973-1997年PCNSL发病率数据来自9个监测、流行病学和最终结果（SEER）登记处。为了限制人类免疫缺陷病毒对发病率的影响，排除了未婚男女和婚姻状况不明者的数据。作为新技术的替代品，SEER数据通过诊断日期（成像替代品）进行审查，并与胶质瘤发生率（立体定向神经外科和改进的诊断神经病理学替代品）进行比较。估计并比较了计算机断层扫描（CT）前（1973-1984年）和磁共振成像（MRI）前（1985-1997年）的年龄调整发病率。使用SEER*STAT.RESULTS进行线性回归分析，计算估计的年变化百分比。在所检查的所有SEER登记中，PCNSL的发生率似乎在增加。所有年龄组的人都表现出这种增长。这种增加在CT时代和MRI时代都被观察到。在相同的登记中，在相同的时间段内，PCNSL的年龄调整发生率（0.15至0.48，增加3倍）超过了系统性淋巴瘤（14.1至18.5，增加33%）。自1985年以来，增长率开始放缓；与1986-1997年相比，1973-1985年期间PCNSL估计的年变化百分比高出3倍。PCNSL的发病率持续上升。这一增长在所有年龄组和男女中都很明显。目前研究的数据表明，改进的诊断工具，如CT或MRI，不能解释这种增加。
BACKGROUND. Primary central nervous system lymphoma (PCNSL) is an extranodal form of non-Hodgkin lymphoma arising in the craniospinal axis. The incidence of PCNSL appears to be increasing.METHODS. PCNSL incidence data from 1973-1997 were obtained from the nine Surveillance, Epidemiology and End Results (SEER) registries. To limit the influence of the human immunodeficiency virus on incidence rates, data of never-married males and females and persons of unknown marital status were excluded. As a surrogate for new technology, SEER data were reviewed by dates of diagnosis (surrogate for imaging) and compared with glioma incidence (surrogate for stereotactic neurosurgery and improved diagnostic neuropathology). Age-adjusted incidence rates were estimated and compared for the period prior to computed tomography (CT) (1973-1984) and the magnetic resonance imaging (MRI) period (1985-1997). The estimated annual percent change was calculated based on linear regression analyses using SEER*STAT.RESULTS. The incidence of PCNSL appears to be increasing in all SEER registries examined. All age groups demonstrated an increase over tune. This increase was observed both in the CT era as well as in the MRI era. PCNSL age-adjusted incidence (0.15 to 0.48, a 3-fold increase) outpaced that of systemic lymphoma (14.1 to 18.5, a 33% increase) for the same registries over the same time periods. The rate of increase has begun to slow since 1985; the estimated annual percent change for PCNSL was three-fold higher during the period 1973-1985 compared with 1986-1997.CONCLUSION. The incidence rate of PCNSL continues to rise. The increase is evident in all age groups and in both genders. Data from the current study suggest that improved diagnostic tools, such as CT or MRI, cannot explain this increase.