The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions
The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions
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DOI：
10.1523/jneurosci.3589-07.2007
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发表时间：
2007-12-05
影响因子：
5.3
通讯作者：
Choi, June-Seek
中科院分区：
文献类型：
--
作者：
Jo, Yong Sang;Park, Eun Hye;Choi, June-Seek
参与模式完成或从碎片线索中提取记忆的大脑回路进行了研究。本研究采用不同版本的Morris水迷宫，探讨了海马CA 3区和内侧前额叶皮层（mPFC）在不同条件下空间记忆提取中的作用。在一个隐藏的平台任务，CA 3和mPFC病变中断部分线索下的记忆提取，但不是在全线索，条件。对于一个延迟匹配到地方的任务，CA 3病变产生了赤字，无论extramaze线索条件下，在形成和回忆空间工作记忆。相比之下，损害mPFC受损的记忆检索只有当一小部分的线索是可用的。为了证实损伤的研究，我们检测了mPFC和海马中立即早期基因c-fos的表达。训练后的空间参考记忆在全线索条件下为6天，同样的训练程序，在没有所有的线索，除了一个增加了Fos免疫反应细胞的数量在mPFC和CA 3。此外，mPFC失活蝇蕈醇，GABA激动剂，阻断记忆检索中的降解线索的环境。然而，最初在单一线索环境中训练的mPFC损伤动物在线索数量增加时检索空间记忆没有困难，这表明上下文变化本身并不损害mPFC损伤动物的行为表现。总之，这些研究结果强烈表明，图案完成需要mPFC和海马之间的相互作用，其中mPFC在检索维持在海马中的空间信息以进行有效导航方面起着重要作用。
Brain circuits involved in pattern completion, or retrieval of memory from fragmented cues, were investigated. Using different versions of the Morris water maze, we explored the roles of the CA3 subregion of the hippocampus and the medial prefrontal cortex (mPFC) in spatial memory retrieval under various conditions. In a hidden platform task, both CA3 and mPFC lesions disrupted memory retrieval under partial-cue, but not under full-cue, conditions. For a delayed matching-to-place task, CA3 lesions produced a deficit in both forming and recalling spatial working memory regardless of extramaze cue conditions. In contrast, damage to mPFC impaired memory retrieval only when a fraction of cues was available. To corroborate the lesion study, we examined the expression of the immediate early gene c-fos in mPFC and the hippocampus. After training of spatial reference memory in full-cue conditions for 6 d, the same training procedure in the absence of all cues except one increased the number of Fos-immunoreactive cells in mPFC and CA3. Furthermore, mPFC inactivation with muscimol, a GABA agonist, blocked memory retrieval in the degraded-cue environment. However, mPFC-lesioned animals initially trained in a single-cue environment had no difficulty in retrieving spatial memory when the number of cues was increased, demonstrating that contextual change per se did not impair the behavioral performance of the mPFC-lesioned animals. Together, these findings strongly suggest that pattern completion requires interactions between mPFC and the hippocampus, in which mPFC plays significant roles in retrieving spatial information maintained in the hippocampus for efficient navigation.