The roles of CD73 in cancer.
The roles of CD73 in cancer.
复制标题
DOI：
10.1155/2014/460654
复制
发表时间：
2014
影响因子：
--
通讯作者：
Zhang HZ
中科院分区：
文献类型：
--
作者：
Gao ZW;Dong K;Zhang HZ
嘌呤能信号传导已成为癌症进展中的重要参与者，并受到一系列核苷酸酶的调节。在酶级联反应中，已发现将AMP分解为腺苷的CD73在许多类型的癌症中过表达。采用多种因素和机制来调节CD73的表达。大量研究表明，CD73是肿瘤细胞体外增殖、迁移和侵袭、肿瘤血管生成和肿瘤免疫逃逸的关键调节分子。由于在癌症中的重要作用，CD73已成为一个有吸引力的治疗靶点。最近在小鼠模型中的证据表明，靶向阻断CD73可能是未来癌症患者的有利治疗方法。本文就CD73在肿瘤发生发展中的作用，包括其临床意义，促进肿瘤生长、转移和血管生成，抑制免疫应答，CD73表达的调控机制以及抗CD73肿瘤治疗的研究现状作一综述。
Purinergic signaling has emerged as an important player in cancer progression and is regulated by a series of nucleotidases. Among the enzyme cascade, CD73, which catelyzes AMP breakdown to adenosine, has been found to be overexpressed in many types of cancer. Various factors and mechanisms are employed to regulate expression of CD73. Accumulating studies have shown that CD73 is a key regulatory molecule of cancer cells proliferation, migration and invasion in vitro, tumor angiogenesis, and tumor immune escape in vivo. With such important roles in cancer, CD73 has become an appealing therapy target. Recent evidences in mice models demonstrated that targeted blockade of CD73 could be a favorable therapeutic approach for cancer patients in the future. In this review, we will summarize the multiple roles of CD73 in cancer development, including its clinical significance, its promotive effects on tumor growth, metastasis, and angiogenesis, and its suppressive effects on immune response, regulatory mechanisms of CD73 expression, and current situation of anti-CD73 cancer therapy.