Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients
Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients
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DOI：
10.1111/bjd.15803
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发表时间：
2018-02-01
影响因子：
10.3
通讯作者：
Garbe, C.
中科院分区：
文献类型：
--
作者：
Teramoto, Y.;Keim, U.;Garbe, C.
肢端雀斑样痣性黑素瘤（acrallentiginousmelanoma，ALM）是皮肤黑素瘤（cutaneousmelanoma，CM）的四种主要亚型之一。尽管ALM的预后比其他CM亚型差，与ALM相关的预后因素仅在小规模队列中得到验证，因为ALM在全球范围内的发病率较低。目的研究ALM的临床特征，并基于德国皮肤病学会中央恶性黑色素瘤登记处（CMMR）的大型数据集评估其预后价值。Meier方法用于估计临床和组织学参数对ALM疾病特异性存活（DSS）曲线的潜在影响，其使用对数秩检验进行比较。一个考克斯比例风险模型被用来确定独立的预后因素为DSS.ResultsIn的，2050例ALM患者被确定从58949例CM记录的CMMR随访数据。在多因素分析中，年龄（P= 0.006），溃疡（P= 0.013），肿瘤厚度（P
BackgroundAcral lentiginous melanoma (ALM) is one of the four major subtypes in cutaneous melanoma (CM). Although ALM has a poorer prognosis than other CM subtypes, the prognostic factors associated with ALM have only been verified in small-sized cohorts because of the low incidence of ALM worldwide.ObjectivesTo investigate the clinical characteristics of ALM and to evaluate their prognostic values based on a large dataset from the Central Malignant Melanoma Registry (CMMR) of the German Dermatologic Society.MethodsThe Kaplan-Meier method was used to estimate the potential influence of clinical and histological parameters on ALM disease-specific survival (DSS) curves, which were compared using the log-rank test. A Cox proportional hazards model was used to identify independent prognostic factors for DSS.ResultsIn total, 2050 patients with ALM were identified from 58949 patients with CM recorded by the CMMR with follow-up data. In multivariate analyses, age (P=0006), ulceration (P=0013), tumour thickness (P