Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis
Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis
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原发性胆汁性肝硬化的肺出血和肾小球肾炎
DOI：
10.1002/hep.1840160609
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发表时间：
1992
期刊：
影响因子：
13.5
通讯作者：
C. Trepo
中科院分区：
文献类型：
--
作者：
F. Bissuel;T. Bizollon;F. Dijoud;P. Boulétreau;J. Cordier;C. Chazot;C. Gouillat;C. Trepo
我们在一位41岁的原发性胆汁性肝硬化女性患者中观察到危及生命的肺内病变和局灶性增生性肾小球肾炎。症状的严重性需要输血和机械通气;患者在皮质类固醇治疗的帮助下有所改善。未发现肺出血肾炎综合征或任何其他明确的系统性血管炎的正式证据。神经元胞浆抗体最初为阳性，免疫抑制治疗3个月后检测不到，无复发。这种关联以前没有描述过，可能会被添加到与原发性胆汁性肝硬化相关的肝外免疫介导疾病列表中。
We observed life‐threatening intrapulmonary hemorrhages and focal proliferative glomerulonephritis in a 41‐yr‐old woman with primary biliary cirrhosis. The severity of the symptoms necessitated blood transfusions and mechanical ventilation; the patient improved with the help of corticosteroid therapy. No formal evidence of either Goodpasture's syndrome or any other well‐defined systemic vasculitis could be found. Neutrophil cytoplasmic antibodies were initially positive and became undetectable after 3 mo of immunosuppressive treatment without relapse. This association has not been described previously and may be added to the list of extrahepatic immune‐mediated conditions associated with primary biliary cirrhosis.
影响因子：
158.5
作者：
FALK, RJ;JENNETTE, JC
通讯作者：
JENNETTE, JC