Dopamine modulates frontomedial failure processing of agentic introverts versus extraverts in incentive contexts
Dopamine modulates frontomedial failure processing of agentic introverts versus extraverts in incentive contexts
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DOI：
10.3758/s13415-013-0228-9
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发表时间：
2014-06-01
影响因子：
2.9
通讯作者：
Stemmler, Gerhard
中科院分区：
文献类型：
--
作者：
Mueller, Erik M.;Burgdorf, Christin;Stemmler, Gerhard
外倾性的代理方面（aE）描述了目标导向行为的个体差异，并与激励环境中的多巴胺功能有关。由于多巴胺可能调节负反馈/失败的处理，aE可能与激励背景下的失败处理有关。为了验证这一假设，N = 86参与者进行了一个虚拟的接球任务。通过展示潜在的奖励和对任务绩效的微妙操纵来创建激励背景，这些奖励和操纵要么是明确的（对照组），要么不是明确的（激励背景组）。为了探索多巴胺的参与，参与者接受安慰剂或选择性多巴胺D2受体拮抗剂舒必利（200 mg）。失败处理通过负反馈诱发的差异额中线θ脑电图功率（DFMT）和反馈相关的负性事件相关电位成分（FRN）进行评估。在引入激励措施之前，DFMT（而不是FRN）与神经质/焦虑有关。重要的是，一旦激励被展示，aE与DFMT，FRN，任务绩效和自我报告的积极情感的变化相关，这进一步取决于激励背景组和/或物质组：在激励背景组中，而不是在对照组中，代理外向者在安慰剂后表现出相对迟钝的DFMT。舒必利显著增强了DFMT，而它降低了FRN的振幅和表现。这些研究结果为当前多巴胺的aE和失败处理模型提供了强有力的支持，也突出了任务背景的重要性。此外，FRN和DFMT的解离表明反馈处理的两个非冗余电生理指标的存在，都与多巴胺和aE有关。
The agency facet of extraversion (aE) describes individual differences in goal-directed behavior and has been linked to dopamine function in incentive contexts. Because dopamine presumably modulates the processing of negative feedback/failure, aE may relate to failure processing in incentive contexts. To test this hypothesis, N = 86 participants performed a virtual ball-catching task. An incentive context was created by displaying potential rewards and subtle manipulations of task performance, which either was (control group) or was not (incentive context group) made explicit. To probe the involvement of dopamine, participants received either placebo or the selective dopamine D2 receptor antagonist sulpiride (200 mg). Failure processing was assessed through negative-feedback-evoked differences in the frontal midline theta electroencephalogram power (DFMT) and in the feedback-related negativity event-related potential component (FRN). Before incentives were introduced, DFMT (but not the FRN) was related to neuroticism/anxiety. Importantly, once incentives were displayed, aE was associated with DFMT, FRN, task performance, and changes in self-reported positive affect, which further depended on incentive context group and/or substance group: In the incentive context group but not in the control group, agentic extraverts showed relatively blunted DFMT after placebo. Sulpiride significantly enhanced DFMT, whereas it reduced FRN amplitudes and performance in agentic extra- versus introverts. These findings provide strong support for current dopamine models of aE and failure processing, and also highlight the importance of task context. Moreover, the dissociations of FRN and DFMT suggest the existence of two nonredundant electrophysiological indices of feedback processing, both relating to dopamine and aE.