Fat consumption and HbA1c levels -: The EPIC-Norfolk Study
Fat consumption and HbA1c levels -: The EPIC-Norfolk Study
复制标题
DOI：
10.2337/diacare.24.11.1911
复制
发表时间：
2001-11-01
期刊：
影响因子：
16.2
通讯作者：
Wareham, NJ
中科院分区：
文献类型：
--
作者：
Harding, AH;Sargeant, LA;Wareham, NJ
目的-描述膳食总脂肪与脂肪摄入模式和糖化血红蛋白(1c)的关系。研究设计和方法-在这项横断面研究中，从人群抽样框架中招募了2,759名男性和3,464名女性(年龄40-78岁)。结果-HbA(1c)水平与饮食的多不饱和脂肪与饱和脂肪比率(P：S比率)呈负相关(在RS比率P<；0.001中，β=-0.0338 HBA(1c)%/SD变化)，而与总脂肪摄入水平正相关(在调整年龄和总能量摄入量后，β=0.0620 HBA(1c)%/SD。在调整了彼此以及总能量、蛋白质、年龄、性别、家族史、糖尿病、体重指数、腰臀比、体力活动和吸烟因素后，相关性仍然显著(对于P：S比率，RS比率中的P=-0.0200 HBA(1c)%，P=0.013；对于总脂肪，β=0.420%HBA(1c)%在总脂肪摄入量中，P<；0,001)。高P：S比率的好处归因于较低的饱和脂肪摄入量。结论--这些发现表明，HBA(1c)正常范围内的HbA(1c)浓度与总脂肪摄入量和饮食脂肪摄入量模式之间存在独立的相关性。它们为促进改变膳食脂肪摄入量的努力提供了进一步的支持。
OBJECTIVE - To describe the relationship between total dietary fat and the pattern Of Fat intake and HbA(1c).RESEARCH DESIGN AND METHODS - in this cross-sectional study, 2,759 men and 3,464 women (40-78 years of age) without a previous diagnosis of type 2 diabetes were recruited from a population-based sampling frame. Diet was assessed using a self-reported semiquantitative food frequency questionnaire.RESULTS- The HbA(1c) level was negatively associated with the polyunsaturated Fat-to-saturated fat ratio (P:S ratio) of the diet (beta = -0.0338 HbA(1c)% per SD change in RS ratio P < 0.001) and positively associated with the total level of fat intake (beta = 0.0620 HbA(1c)% per SD change in total fat intake P < 0.001), adjusted for age and total energy intake. The associations remained significant when adjusted for each other and for total energy, protein, age, sex, family history, of diabetes, BMI, waist-to-hip ratio, physical activity, and smoking (for P:S ratio, P = -0.0200 HbA(1c)% per SD change in RS ratio, P = 0.013; for total fat, beta = 0.420% HbA(1c)% per SD change in total fat intake, P < 0,001). The benefits from a high P:S ratio were attributed to a lower saturated fat intake.CONCLUSIONS - These findings demonstrate independent associations between HbA(1c) concentration across the normal range of HbA(1c) and both total fat intake and the pattern of dietary fat intake. They provide further support to efforts promoting modifications in the intake of dietary fat.