Lack of Association of P2RX7 Gene rs2230912 Polymorphism with Mood Disorders: A Meta-Analysis
Lack of Association of P2RX7 Gene rs2230912 Polymorphism with Mood Disorders: A Meta-Analysis
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DOI：
10.1371/journal.pone.0088575
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发表时间：
2014-02-12
期刊：
影响因子：
3.7
通讯作者：
Liu, Juan
中科院分区：
文献类型：
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作者：
Feng, Wen-Ping;Zhang, Bo;Liu, Juan
背景资料：方法：数据来源于PubMed、Excerpta Medica Database、Elsevier Science Direct、科克伦图书馆、中国生物医学文献数据库，最后一次报告截止到2013年4月1日。比值比（OR）和95%置信区间（CI）用于评估相关性的强度。结果：共检索到13个独立的研究（6，962例病例和9，262例对照），采用固定效应模型（Mantel-Haenszel）或随机效应模型（DerSimonian-Laird）进行汇总OR。我们检测到显著的研究间异质性。该基因多态性与心境障碍无显著相关性（P>0.05）。我们还对单相抑郁症和双相情感障碍进行了疾病特异性荟萃分析。该基因多态性与单相抑郁和双相情感障碍无显著关联（P>0.05）。此外，我们对不同类型的病例进行了亚组分析。在临床队列和人群队列中，该多态性与心境障碍无显著相关性（P>0.05）。在以家族为基础的队列中，发现该多态性与心境障碍的等位基因对比显著相关（OR = 1.26，95%CI = 1.05-1.50，P = 0.01）。结论：总体而言，我们的荟萃分析表明，P2 RX 7基因rs 2230912多态性可能不会有助于使用病例对照设计的发展心境障碍的风险。鉴于不同类型病例的亚组分析不一致，仍需进行更大样本量的进一步研究。
Background: To assess the association of P2RX7 gene rs2230912 polymorphism with mood disorders using a meta-analysis.Methods: Data were collected from the following electronic databases: PubMed, Excerpta Medica Database, Elsevier Science Direct, Cochrane Library, and Chinese Biomedical Literature Database, with the last report up to April 1, 2013. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. Dependent on the results of heterogeneity test among individual studies, the fixed effect model (Mantel-Haenszel) or random effect model (DerSimonian-Laird) was selected to summarize the pooled OR.Results: We identified 13 separate studies using search (6,962 cases and 9,262 controls). We detected significant between-study heterogeneity. No significant association of this polymorphism with mood disorders was found (P>0.05). We also performed disease-specific meta-analysis in unipolar depression and bipolar disorder. No significant association of this polymorphism with unipolar depression or bipolar disorder was found (P>0.05). Additionally, we performed subgroup analysis by different types of cases. No significant association of this polymorphism with mood disorders in clinical cohorts or population-based cohorts (P>0.05). A significant association of this polymorphism with mood disorders was found for the allele contrast in family-based cohorts (OR = 1.26, 95% CI = 1.05-1.50, P = 0.01).Conclusions: Overall, our meta-analysis suggests that P2RX7 gene rs2230912 polymorphism may not contribute to the risk of developing mood disorders using a case-control design. Given the discordance in the subgroup analysis by different types of cases, further studies based on larger sample size are still needed.