Sleep disturbances in schizophrenia spectrum and bipolar disorders - a transdiagnostic perspective
Sleep disturbances in schizophrenia spectrum and bipolar disorders - a transdiagnostic perspective
复制标题
DOI：
10.1016/j.comppsych.2019.02.006
复制
发表时间：
2019-05-01
影响因子：
7.3
通讯作者：
Aas, Monica
中科院分区：
文献类型：
--
作者：
Laskemoen, Jannicke Fjaera;Simonsen, Carmen;Aas, Monica
背景：睡眠障碍在严重精神障碍中普遍存在，但其诊断类型和频率尚未在大规模研究中进行调查。方法：精神分裂症谱系障碍（SCZ, (N = 617)）、双相情感障碍（BD, (N = 440)）患者。健康对照（HC, (N = 173)）纳入研究。睡眠障碍（失眠、嗜睡和睡眠阶段延迟）是根据抑郁症状清单-临床医生评定量表的项目来确定的。临床症状采用阳性和阴性综合征量表评估，功能水平采用整体功能量表评估。结果：睡眠障碍发生率SZ组为78%，BD组为69%，HC组为39%。失眠是所有人群中最常见的睡眠障碍。两个诊断组报告的睡眠障碍明显多于HC组（P < 0.001）。在诊断组中，睡眠障碍与更严重的阴性和抑郁症状以及更低的功能相关（P < 0.001, eta(2) = 0.0071）。嗜睡是唯一与既往治疗史相关的睡眠障碍。结论：睡眠障碍，包括失眠、嗜睡和睡眠阶段延迟，在SCZ和BD中很常见，并且在诊断组中与更严重的临床症状相关。这表明睡眠障碍是一种临床相关的跨诊断现象。(C) 2019作者。Elsevier Inc.出版。
Background: Sleep disturbances are prevalent in severe mental disorders but their type and frequency across diagnostic categories has not been investigated in large scale studies.Methods: Participants with Schizophrenia spectrum disorders (SCZ, (N = 617)), Bipolar disorders (BD, (N = 440)). and Healthy Controls (HC, (N = 173)) were included in the study. Sleep disturbances (insomnia, hypersomnia and delayed sleep phase) were identified based on items from the Inventory of Depressive Symptoms - Clinician rated scale. Clinical symptoms were assessed with the Positive and Negative Syndrome scale and level of functioning with the Global assessment of Functioning scale.Results: The rate of any sleep disturbance was 78% in SZ, 69% in BD and 39% in HC. Insomnia was the most frequently reported sleep disturbance across all groups. Both diagnostic groups reported significantly more of any sleep disturbances than HC (P < 0.001). Having a sleep disturbance was associated with more severe negative and depressive symptoms and with lower functioning across diagnostic groups (P < 0.001, eta(2) = 0.0071). Hypersomnia was the only sleep disturbance associated with previous treatment history.Conclusion: Sleep disturbances, including insomnia, hypersomnia and delayed sleep phase, are frequent in SCZ and BD, and associated with more severe clinical symptomatology across diagnostic groups. This suggests that sleep disturbance is a clinically relevant transdiagnostic phenomenon. (C) 2019 The Authors. Published by Elsevier Inc.