Lipid peroxidation and antioxidant status in children with acute purulent meningitis and encephalitis
Lipid peroxidation and antioxidant status in children with acute purulent meningitis and encephalitis
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DOI：
10.1080/00207450490249383
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发表时间：
2004-01-01
影响因子：
2.2
通讯作者：
Cemek, F
中科院分区：
文献类型：
--
作者：
Çaksen, H;Cemek, M;Cemek, F
在这项研究中，脂质过氧化和抗氧化状态的儿童急性细菌性脑膜炎和脑炎进行了调查。其目的是确定自由基是否可能在儿童脑膜炎和脑炎中发挥作用。我们的研究包括16名急性细菌性脑膜炎患儿，13名脑炎患儿和17名对照组。研究了所有受试者入院6小时内的血清丙二醛（MDA）、还原型谷胱甘肽（GSH）、维生素C、维生素E、β-胡萝卜素和视黄醇水平。两组间血清MDA、GSH和维生素C的差异有统计学意义。与对照组相比，研究组的血清MDA和维生素C水平较高，血清GSH水平较低。维生素C水平在脑炎组和对照组中相似，但脑炎组儿童的维生素C水平显著低于脑膜炎组。总之，我们的研究表明，血清MDA和GSH水平在脑膜炎和脑炎的儿童都受到影响，但维生素C水平只在脑膜炎的儿童受到影响。血清维生素E，β-胡萝卜素和视黄醇水平没有改变儿童脑膜炎和脑炎。
In this study, lipid peroxidation and antioxidant status were investigated in children with acute bacterial meningitis and encephalitis. The aim was to determine whether there was a possible role of free radicals in meningitis and encephalitis in childhood. Our study included 16 children with acute bacterial meningitis, 13 with encephalitis, and 17 control subjects. Serum malondialdehyde (MDA), reduced glutathione (GSH), vitamin C, vitamin E, beta-carotene, and retinol levels were studied in all subjects within 6 h of admission. There was a statistically significant difference for serum MDA, GSH, and vitamin C between the groups. Serum MDA and vitamin C levels were higher, and serum GSH levels were lower in the study groups compared to the control group. Vitamin C levels were similar in both the encephalitis and control groups, but they were significantly lower in the children with encephalitis than the meningitis group. In conclusion, our study showed that serum MDA and GSH levels were affected in children with both meningitis and encephalitis, but vitamin C level was affected only in children with meningitis. Serum vitamin E, beta-carotene, and retinol levels were not changed in childhood meningitis and encephalitis.