Fructose and Vitamin C Intake Do Not Influence Risk for Developing Hypertension
Fructose and Vitamin C Intake Do Not Influence Risk for Developing Hypertension
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DOI：
10.1681/asn.2008050473
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发表时间：
2009-04-01
影响因子：
13.6
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
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作者：
Forman, John P.;Choi, Hyon;Curhan, Gary C.
高尿酸水平与高血压的风险增加有关。果糖摄入量增加会增加血浆尿酸水平，维生素C摄入量增加会降低尿酸水平，但这些营养素是否与高血压风险独立相关尚不清楚。我们通过分析三个大型独立前瞻性队列的参与者的数据来研究这个问题：护士健康研究1（n = 88，540），护士健康研究2（n = 97，315）和卫生专业人员随访研究（n = 37，375）。采用多变量考克斯比例风险回归，根据果糖摄入量的五分位数和维生素C摄入量的类别计算高血压发生的相对风险和95%置信区间。果糖摄入量与高血压风险无关;多变量相对危险度果糖摄入量最高与最低的五分位数（95%置信区间）分别为1.02（0.99至1.06）在护士健康研究1，1.03（0.98至1.08）在护士健康研究2，和0.99（0.93至1.05）在卫生专业人员随访研究。关于维生素C，与每天摄入>= 1500 mg维生素C的人相比，
Higher uric acid levels are associated with an increased risk for developing hypertension. Higher intake of fructose increases plasma uric acid levels and higher intake of vitamin C reduces uric acid levels, but whether these nutrients are independently associated with the risk for developing hypertension is unknown. We studied this question by analyzing data from participants of three large and independent prospective cohorts: Nurses' Health Study 1 (n = 88,540), Nurses' Health Study 2 (n = 97,315), and the Health Professionals Follow-up Study (n = 37,375). Relative risks and 95% confidence intervals for incident hypertension were computed according to quintiles of fructose intake and categories of vitamin C intake using multivariable Cox proportional hazards regression. Fructose intake was not associated with the risk for developing hypertension; the multivariable relative risks (95% confidence intervals) for the highest compared with the lowest quintile of fructose intake were 1.02 (0.99 to 1.06) in Nurses' Health Study 1, 1.03 (0.98 to 1.08) in Nurses' Health Study 2, and 0.99 (0.93 to 1.05) in Heath Professionals Follow-up Study. Regarding vitamin C, the relative risks for individuals who consumed >= 1500 mg/d compared with those who consumed