Minimizing potential resistance: The molecular view
Minimizing potential resistance: The molecular view
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DOI：
10.1086/321840
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发表时间：
2001-09-15
影响因子：
11.8
通讯作者：
Trieu-Cuot, P
中科院分区：
文献类型：
--
作者：
Courvalin, P;Trieu-Cuot, P
分子生物学对抗生素耐药性研究的主要贡献是阐明了几乎所有的耐药性生化机制和细菌间遗传信息的传播途径。在这篇综述中，我们考虑了分子生物学对抵抗耐药细菌进化的潜在贡献。特别是，我们强调的事实是，基本方法对最大限度地减少潜在的耐药性有直接的实际影响：通过改善耐药表型的解释，通过提供更充分的人类治疗，通过促进更谨慎地使用抗生素，并通过允许合理设计新药，规避现有的耐药机制或解决未开发的目标。
The major contribution of molecular biology to the study of antibiotic resistance has been the elucidation of nearly all biochemical mechanisms of resistance and the routes for dissemination of genetic information among bacteria. In this review, we consider the potential contribution of molecular biology to counteracting the evolution of resistant bacteria. In particular, we emphasize the fact that fundamental approaches have had direct practical effects on minimizing potential resistance: by improving interpretation of resistance phenotypes, by providing more adequate human therapy, by fostering more prudent use of antibiotics, and by allowing the rational design of new drugs that evade existing resistance mechanisms or address unexploited targets.