Human immunodeficiency virus glycoprotein-specific CD4+ cytotoxic T lymphocytes are involved in two types of cytotoxicity: antigen-specific and cell-cell fusion-related cell lysis.
Human immunodeficiency virus glycoprotein-specific CD4+ cytotoxic T lymphocytes are involved in two types of cytotoxicity: antigen-specific and cell-cell fusion-related cell lysis.
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人类免疫缺陷病毒糖蛋白特异性 CD4 细胞毒性 T 淋巴细胞参与两种类型的细胞毒性：抗原特异性和细胞-细胞融合相关的细胞裂解。
DOI：
10.1089/aid.1997.13.1017
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Jassoy,C
中科院分区：
文献类型：
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作者：
Ehret,R;Heinkelein,M;Siliciano,RF;Jassoy,C
人类免疫缺陷病毒（HIV）糖蛋白特异性CD4+细胞毒性T淋巴细胞（ctl）以mhc限制性钙依赖性方式裂解靶细胞，类似于CD8+ ctl使用的机制。然而，在铬释放试验中，未启动的外周血CD4+T细胞与表达HIV糖蛋白的细胞接触已被证明除了细胞融合外，还会引起快速的细胞溶解，这可能类似抗原特异性细胞毒性。在这项研究中，我们检测了糖蛋白特异性CD4+ ctl进行类似的融合相关细胞溶解的能力。获得的数据表明，除了抗原特异性钙依赖性细胞毒性外，包膜特异性CD4+ ctl还参与融合相关的钙非依赖性细胞溶解。
Human immunodeficiency virus (HIV) glycoprotein-specific CD4+cytotoxic T lymphocytes (CTLs) lyse target cells in an MHC-restricted calcium-dependent fashion similar to the mechanism used by CD8+CTLs. However, contact of unprimed peripheral blood CD4+T cells with HIV glycoprotein-expressing cells has been shown to cause, in addition to cell-cell fusion, rapid cytolysis that may resemble antigen-specific cytotoxicity in the chromium release assay. In this study, the ability of glycoprotein-specific CD4+CTLs to undergo similar fusion-related cytolysis was examined. The data obtained demonstrate that in addition to antigen-specific calcium-dependent cytotoxicity, envelope-specific CD4+CTLs are involved in fusion-related, calcium-independent cytolysis.