Bone Mass and Body Composition in Children and Adolescents With Primary Hypertension: Preliminary Data
Bone Mass and Body Composition in Children and Adolescents With Primary Hypertension: Preliminary Data
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原发性高血压儿童和青少年的骨量和身体成分：初步数据
DOI：
10.1161/hypertensionaha.107.100602
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发表时间：
2008
期刊：
影响因子：
8.3
通讯作者：
R. Lorenc
中科院分区：
文献类型：
--
作者：
P. Płudowski;M. Litwin;Joanna Śladowska;J. Antoniewicz;A. Niemirska;A. Wierzbicka;R. Lorenc
由于原发性高血压 (PH) 与钙代谢相关，因此推测 PH 可能与骨质疏松风险相关。该研究旨在评估青少年高血压患者的身体成分与骨强度之间的关系。使用 X 射线吸收测定法（DPX-L，GE Healthcare）对 94 名 6 至 18 岁的 PH 儿童（21 名女孩和 73 名男孩）进行全身扫描。使用健康对照受试者的参考来计算 Z 分数（年龄和性别匹配）、SD 分数（身高和性别匹配）和 SDs 分数（体重和性别匹配）。调查了全身骨矿物质密度、全身骨矿物质含量（TBBMC）、去脂体重（LBM）和脂肪量（FM）。相对骨强度指数计算为 TBBMC:LBM 比率。 Z 评分证明，PH 病例受试者的总体骨密度、TBBMC 和 LBM 略高于健康受试者。与健康受试者相比，女孩和男孩的LBM/体重（BW）Z得分分别降低了-1.9±1.5和-1.2±1.4，FM Z得分增加了+2.5±2.5和+1.7±2.0，FM/BW Z得分增加了+1.6±1.3和+1.1±1.4（P<0.001）。当控制体重增加时，PH女孩的LBM（−1.4±1.7；P<0.01）、FM（+1.6±2.2；P<0.05）、FM/BW（+0.9±1.0；P<0.05）和FM/LBM（+1.3±1.4；P<0.01）的SD评分存在差异，但总体骨矿物质密度没有差异(+0.2±1.0；P值不显着)、TBBMC(-1.2±1.6；P=0.07)、LBM/BW(-0.7±1.0；P=0.07)和TBBMC/LBM(-1.0±2.1；P值不显着)，与各自的SD评分-0.3±1.1、+0.3±1.1、+0.3±1.0相比， PH 男孩为+0.3±1.0、-0.2±1.0、-0.6±1.9、-0.3±1.0 和-0.2±1.0。总之，PH 青少年的 FM 增加，并且 BW、FM 和 LBM 之间的关系不平衡。在 PH 女孩中，骨强度虽然适合实际年龄和身高，但低于 BW 的预期。
Because primary hypertension (PH) is associated with calcium metabolism, it is hypothesized that PH may be related to osteoporosis risk. The study aimed to evaluate the relationship between body composition and bone strength in hypertensive adolescents. Total body scans using x-ray absorptiometry (DPX-L, GE Healthcare) were performed in 94 PH children aged 6 to 18 years (21 girls and 73 boys). References of healthy control subjects were used for the calculation of Z scores (age and gender matched), SD scores (height and gender matched), and SDs scores (weight and gender matched). Total body bone mineral density, total body bone mineral content (TBBMC), lean body mass (LBM), and fat mass (FM) were investigated. Relative bone strength index was calculated as the TBBMC:LBM ratio. As evidenced by Z scores, PH case subjects had slightly higher total body bone mineral density, TBBMC, and LBM compared with healthy subjects. Reduced LBM/body weight (BW) Z scores of −1.9±1.5 and −1.2±1.4, increased FM Z scores of +2.5±2.5 and +1.7±2.0, and increased FM/BW Z scores of +1.6±1.3 and +1.1±1.4 were noted in girls and boys compared with healthy subjects, respectively (P<0.001). When increased BW was controlled for, PH girls differed in SDs scores for LBM (−1.4±1.7; P<0.01), FM (+1.6±2.2; P<0.05), FM/BW (+0.9±1.0; P<0.05), and FM/LBM (+1.3±1.4; P<0.01) but not for total body bone mineral density (+0.2±1.0; P value not significant), TBBMC (−1.2±1.6; P=0.07), LBM/BW (−0.7±1.0; P=0.07), and TBBMC/LBM (−1.0±2.1; P value not significant), when compared with respective SDs scores of −0.3±1.1, +0.3±1.1, +0.3±1.0, +0.3±1.0, −0.2±1.0, −0.6±1.9, −0.3±1.0, and −0.2±1.0 in PH boys. In conclusion, PH adolescents had increased FM and an imbalanced relationship among BW, FM, and LBM. In PH girls, bone strength, although proper for chronological age and body height, was lower than expected for BW.
影响因子：
158.5
作者：
Weiss, R;Dziura, J;Caprio, S
通讯作者：
Caprio, S
患有神经性厌食症的青春期女孩骨密度下降。
影响因子：
8
作者：
Bachrach,LK;Guido,D;Katzman,D;Litt,IF;Marcus,R
通讯作者：
Marcus,R
影响因子：
3.3
作者：
Gilsanz, V
通讯作者：
Gilsanz, V