2-Propanephosphonic acid anhydride (T3P)-mediated segment coupling and head-to-tail cyclization of sterically hindered peptides
2-Propanephosphonic acid anhydride (T3P)-mediated segment coupling and head-to-tail cyclization of sterically hindered peptides
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DOI：
10.1039/a905021c
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发表时间：
1999-09-21
影响因子：
4.9
通讯作者：
Henklein, P
中科院分区：
文献类型：
--
作者：
Klose, J;Bienert, M;Henklein, P
在通过环化模型序列比较HOAt衍生的偶联剂（HAPyU）和基于膦酸的缩合剂（T3 P）的有效性的过程中，我们发现当在环化位点发现空间位阻氨基酸时，T3 P在将线性肽转化为立体化学完整的环状单体方面是上级试剂。
In the course of comparing the effectiveness of an HOAt-derived coupling reagent (HAPyU) and a phosphonic acid-based condensation agent (T3P) by cyclization of model sequences, we found that T3P was a superior reagent with regard to conversion of the linear peptide into the stereochemically intact cyclic monomer when sterically hindered amino acids are found at the cyclization site.