Overactive bladder in adults with sickle cell disease.
Overactive bladder in adults with sickle cell disease.
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DOI：
10.1002/nau.22777
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发表时间：
2016-06
影响因子：
2
通讯作者：
Burnett AL
中科院分区：
文献类型：
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作者：
Anele UA;Morrison BF;Reid ME;Madden W;Foster S;Burnett AL
目的研究成人镰状细胞病(SCD)人群中夜间遗尿和膀胱过度活动(OAB)症状的发生率及其影响。我们从2012年10月至2014年2月对成年SCD患者进行了一项单中心横断面研究，使用经过验证的辉瑞OAB简式问卷和简短的排尿史调查。将患者的反应和评分与具有正常或镰状细胞特征的血红蛋白基因型的对照组进行比较。将239例SCD患者(男性116例，女性123例)与104例正常和57例镰状细胞特征患者进行比较。239例SCD患者中有7例(2.9%)报告了当前的夜间遗尿，而161例非SCD患者中没有一例报告有夜间遗尿(p=0.04)。SCD患者夜间遗尿停止的中位年龄(12.0，IQR9.0-15.0岁)高于正常组(7.5，IQR6.0-9.8岁)和镰状细胞组(7.5，IQR6.0-8.8)(p<；0.0001)。93例(38.9%)的SCD患者有93例(38.9%)的症状评分，相比之下，10 4例正常患者中有17例(16.3%)和57例镰状细胞病患者中有11例(19.3%)具有指示OAB症状的评分(p<；0.0001)。与正常组和镰状细胞组相比，SCD患者的OAB症状严重程度更高，健康相关生活质量得分更低(分别为P<；0.0001和P<；0.0001)。我们证明在成年SCD人群中夜间遗尿和OAB症状的发生率升高。OAB表型可能是SCD的一种未被认识的并发症，与年龄无关。
To characterize the prevalence and impact of nocturnal enuresis and overactive bladder (OAB) symptomatology in the adult sickle-cell disease (SCD) population. We performed a single-center, cross-sectional study of adult SCD patients from October 2012 to February 2014, using the validated Pfizer OAB short form questionnaire and brief voiding history surveys. Patient responses and scores were compared to that of controls having normal or sickle cell trait hemoglobin genotypes. A group of 239 SCD patients (116 males, 123 females) were compared with 104 normal and 57 sickle cell trait patients. Seven of 239 (2.9%) SCD patients compared to none of the 161 patients without SCD (p = 0.04) reported current nocturnal enuresis. The median age of nocturnal enuresis cessation was higher in SCD patients (12.0, IQR 9.0–15.0 yrs) compared to that of both normal (7.5, IQR 6.0–9.8 yrs) and sickle cell trait (7.5, IQR 6.0–8.8) groups (p <0.0001). Ninety-three of 239 (38.9%) SCD patients compared to 17 of 104 (16.3%) normal and 11 of 57 (19.3%) sickle cell trait had scores indicating OAB symptomatology (p < 0.0001). Patients with SCD had higher OAB symptom severity and lower Health-Related Quality of Life scores compared to the normal and sickle cell trait groups (p < 0.0001 and p < 0.0001, respectively). We demonstrate an elevated rate of nocturnal enuresis and OAB symptoms in the adult SCD population. An OAB phenotype may be an under-recognized complication of SCD irrespective of age.